ID   A0A2G5U715_9PELO        Unreviewed;      1156 AA.
AC   A0A2G5U715;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   RecName: Full=CYRIA/CYRIB Rac1 binding domain-containing protein {ECO:0000259|Pfam:PF07159};
GN   Name=Cni-gex-2 {ECO:0000313|EMBL:PIC35332.1};
GN   Synonyms=Cnig_chr_IV.g14723 {ECO:0000313|EMBL:PIC35332.1};
GN   ORFNames=B9Z55_014723 {ECO:0000313|EMBL:PIC35332.1};
OS   Caenorhabditis nigoni.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=1611254 {ECO:0000313|EMBL:PIC35332.1, ECO:0000313|Proteomes:UP000230233};
RN   [1] {ECO:0000313|Proteomes:UP000230233}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JU1422 {ECO:0000313|Proteomes:UP000230233};
RA   Yin D., Schwarz E.M., Thomas C.G., Felde R.L., Korf I.F., Cutter A.D.,
RA   Schartner C.M., Ralston E.J., Meyer B.J., Haag E.S.;
RT   "Rapid genome shrinkage in a self-fertile nematode reveals novel sperm
RT   competition proteins.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the CYFIP family.
CC       {ECO:0000256|ARBA:ARBA00025790}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PIC35332.1}.
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DR   EMBL; PDUG01000004; PIC35332.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2G5U715; -.
DR   STRING; 1611254.A0A2G5U715; -.
DR   Proteomes; UP000230233; Chromosome iv.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro.
DR   InterPro; IPR009828; CYRIA/CYRIB_Rac1-bd.
DR   InterPro; IPR008081; Cytoplasmic_FMR1-int.
DR   PANTHER; PTHR12195:SF0; CYTOPLASMIC FMR1-INTERACTING PROTEIN; 1.
DR   PANTHER; PTHR12195; CYTOPLASMIC FMR1-INTERACTING PROTEIN-RELATED; 1.
DR   Pfam; PF07159; CYRIA-B_Rac1-bd; 1.
DR   Pfam; PF05994; FragX_IP; 1.
DR   PIRSF; PIRSF008153; FMR1_interacting; 1.
DR   PRINTS; PR01698; CYTOFMRPINTP.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000230233}.
FT   DOMAIN          61..275
FT                   /note="CYRIA/CYRIB Rac1 binding"
FT                   /evidence="ECO:0000259|Pfam:PF07159"
FT   REGION          524..549
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        534..548
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1156 AA;  133170 MW;  B705ACD9804753AD CRC64;
     MSNNVSLEAA LNNVSLLDMI VVPDDQPDIE ARALPLLYRA NFDTNFEDRS AFVTGIAKYS
     EEATRHAQFN DMLAEGLQHA ANLYTWRCCS RAVPMAKSND QPNRTEINEM VVNVLKPEVS
     KLNSFMRFTL HAIQRFCEEV RRLCHSEKRK DFVSEAYLLT LGRFINMFAV LDELKNMKAS
     IKNDFSTFRR ASQFLQTMSD TQAIHDMQNL SMFLATQNKI KDDLKLQMKT IEGYEELLSD
     VVNICAHMYE QQLYISPNEK HMFVKVIAFS LFLMDGDAAN VAKLDQKKRL SIQRLDKIFK
     SLEVVPLYGD MQIQPFAFVR RSSHYEANKW PLSDKESEKC HVNIVEKVHT IRSDHESYVT
     QFAKINNEVA ISDRVGSDRE HRELTSLALS GIQLLCQWSC AVVETISWKL LHPTNPKDNR
     ECPDTAEEYE RATRYNYTPA EKTALIQIIA MIKGLQSMLG KMEPEMSNAT RKCVYVELQA
     FIQHTVNEPL QKAIKNKKDL LASILQSVKD SICDVGYELN RMTDTKSKSK KSGSKVDSAN
     SSSSDIRIPR RTAAPGSTQL YMARTQLESL ISEKLCGGKK ILRKELDSKT IEKISVFLRK
     SAHWPALFKF SDSMTEAGEL SQLWFREFYL EMTMGQRIQF PIEMSMPWIL TDYILSCDEH
     SLIESALYQL DLYNDAAQYS LFSFNKQFLY DEVEAEVNLC FDQFVYKLSE MVFTNYKQLA
     SSMLLDKRFK SELSRVGTII RTPTASRFET LLQQRHVQLL GRSVDLNRVV SQRINMSLLK
     ALDAAIWKFE SEPLSSIIEL DMLIEANRLC HSLLKEVLHS LAPFDDIFQE ANHAVNSPHG
     RITLHVFWEL NYDFVPNFVY NGSTHRFVRA KQYFRKTPAR EKPPQVGQVY YWGSKSLMAA
     FMNISNGYNS CIGTQHLKAI TRLLHYQGIA VILDELLKMT HRLLEEKIKR HVRNVFNMMP
     KVLKLPRADY GSNALLQYYC HHLDAVGKYP ELKSEFCQDL RELGNMIVFC QQLEVALGQE
     ETHDLFLAAA FIGNVPQPPS RNAQEQMKQL AKLEEKYARI HLSEVIAKNT NDEGQAIIAK
     EAELMTKERL CCGLNVFENF LLRIKQILAN DEIWTGGYPT NGVFWIDECV EWYRVYSALQ
     FFLCQPTRDD NEVYAE
//