ID A0A2G5UG69_9PELO Unreviewed; 1682 AA.
AC A0A2G5UG69;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Clathrin heavy chain {ECO:0000256|PIRNR:PIRNR002290};
GN Name=Cni-chc-1 {ECO:0000313|EMBL:PIC38557.1};
GN Synonyms=Cnig_chr_III.g10536 {ECO:0000313|EMBL:PIC38557.1};
GN ORFNames=B9Z55_010536 {ECO:0000313|EMBL:PIC38557.1};
OS Caenorhabditis nigoni.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=1611254 {ECO:0000313|EMBL:PIC38557.1, ECO:0000313|Proteomes:UP000230233};
RN [1] {ECO:0000313|Proteomes:UP000230233}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JU1422 {ECO:0000313|Proteomes:UP000230233};
RA Yin D., Schwarz E.M., Thomas C.G., Felde R.L., Korf I.F., Cutter A.D.,
RA Schartner C.M., Ralston E.J., Meyer B.J., Haag E.S.;
RT "Rapid genome shrinkage in a self-fertile nematode reveals novel sperm
RT competition proteins.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Clathrin is the major protein of the polyhedral coat of
CC coated pits and vesicles. {ECO:0000256|PIRNR:PIRNR002290}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane, coated pit
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the clathrin heavy chain family.
CC {ECO:0000256|ARBA:ARBA00009535, ECO:0000256|PIRNR:PIRNR002290}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIC38557.1}.
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DR EMBL; PDUG01000003; PIC38557.1; -; Genomic_DNA.
DR STRING; 1611254.A0A2G5UG69; -.
DR Proteomes; UP000230233; Chromosome iii.
DR GO; GO:0030132; C:clathrin coat of coated pit; IEA:InterPro.
DR GO; GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
DR GO; GO:0071439; C:clathrin complex; IEA:InterPro.
DR GO; GO:0032051; F:clathrin light chain binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.25.40.730; -; 1.
DR Gene3D; 2.130.10.110; Clathrin heavy-chain terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR015348; Clathrin_H-chain_linker_core.
DR InterPro; IPR016025; Clathrin_H-chain_N.
DR InterPro; IPR022365; Clathrin_H-chain_propeller_rpt.
DR InterPro; IPR016341; Clathrin_heavy_chain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR10292:SF1; CLATHRIN HEAVY CHAIN; 1.
DR PANTHER; PTHR10292; CLATHRIN HEAVY CHAIN RELATED; 1.
DR Pfam; PF00637; Clathrin; 7.
DR Pfam; PF09268; Clathrin-link; 1.
DR Pfam; PF13838; Clathrin_H_link; 1.
DR Pfam; PF01394; Clathrin_propel; 5.
DR PIRSF; PIRSF002290; Clathrin_H_chain; 1.
DR SMART; SM00299; CLH; 7.
DR SUPFAM; SSF48371; ARM repeat; 6.
DR SUPFAM; SSF50989; Clathrin heavy-chain terminal domain; 1.
DR PROSITE; PS50236; CHCR; 7.
PE 3: Inferred from homology;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176, ECO:0000256|PIRNR:PIRNR002290};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329,
KW ECO:0000256|PIRNR:PIRNR002290};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR002290};
KW Reference proteome {ECO:0000313|Proteomes:UP000230233};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 330..353
FT /note="Clathrin heavy chain linker core motif"
FT /evidence="ECO:0000259|Pfam:PF09268"
FT REGION 1617..1636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1682 AA; 191561 MW; BF574B566CB6728A CRC64;
MAALPIKFHE HLQLPNAGIR VPNITFSNVT MESDKNIVVR EMIGDQQQVV IIDLADTANP
TRRPISADSV IMHPTAKILA LKSGKTLQIF NIELKAKVKA HQNVEDVVYW KWISDKLIAL
VSDTAVYHWS IEGDAAPVKM FDRHQSLAGT QIINYRADAE NKWLVLIGIS AKDSRVVGSM
QLYSTERKVS QPIEGHAASF VRFKVDGNQQ PSNLFCFSVK TETGGKLHII EVGTPATGNS
PFQKKNVDVP YTADTAGDFP VSMQVSTKQG IIYLVTKQGY VHLYDVESGL RIYSNRISTD
TVFVTCEYTA TGGIMGINRK GQVLSVSIDE ANLVPFVTNQ LQNPDLALKL AVRCDLPGAE
ELFVRKFNLL FSNGQFGEAA KVAASAPQGI LRTPATIQKF QQCPSTGSGP SPLLQFFGIL
LDQGKLNKYE TLELCRPVLA QGRKELITKW LNEQKLECCE ELGDLIKPHD VNTALSVYLR
GNVPHKVVQS FAETGQFDKI VMYAKRVGFQ PDYLFQLRQI LRNSNPDNGA KFAQLLVSES
ENGEPLADLS QIIDCFMEVQ AVQPCTSFLL EVLKGDKPEE GHLQTRLLEM NLLAAPAVAD
AILANKMFSH YDRPAIGQLC EKAGLLQRAL EHFTDLYDIK RTVVHTHLLK PDWLVGYFGS
LSVEDSLECL KAMLTQNIRQ NLQVVVQIAS KYHEQLGADK LTEMFETHKS YEGLFYFLGS
IVNFSQDPEV HFKYIQAATR TGQIKEVERI CRESQCYDAE RVKNFLKEAK LNDQLPLIIV
CDRHNMVHDL VLYLYRNQLQ KYIEVFVQKV NAARLPIVVG ALLDVDCSED AIKQLIINTR
GKFDIDELVE EVEKRNRLKL LNHWLESRIQ EGATDAATHN AMAKIYIDSN NNPERFLKEN
PYYDSKVVGK YCEKRDPHYA FLSYERGQCD AELINVCNEN SLFKNLARYL VKRRDFTLWE
QVLNEENVYR RQLIDQVVQT ALSETQDPED ISVTVKAFMA ADLPNELIEL LEKIVLDNSA
FSEHRNLQNL LILTAMRADR TRVMEYIQKL DNYDAPDIAN IAITSELYEE AFAIFKKFDV
NSSAINVLIE NVNNLDRAYE FAEKCNQSDV WASLAKAQLK QDLVKEAVDS FIKADDPGAY
MEVVNKCSQT EHWEDLVRYL QMARKKSRES YIETELVYAL AKTGRLTELE EFIAGPNHAQ
IGQIGDRCFD NGMFDAAKIL FNNVSNFAKL SVTLVRLGEY QGAVDAARKA NSTKTWKQVC
FSCVENGEFR LAQMCGLHIV VHADELEELI NFYQDRGHFE ELIALLEAAL GLERAHMGMF
TELAILYSKY KPEKMREHLE LFWSRVNIPK VLRAAEQAHL WSELVFLYDK YEEYDNAALT
MMQHPTESWR EQHFKEVIAK VANVELYYKA MQFYLDFKPL LLNDLLAVLS PRLDHSRTVL
FFNKLKQIPL VKPYLRQVQN LNNKAINEAL NQLLIDEEDH AGLRSSIEAQ DNFDNISLAQ
QLEKHPLVEF RRISAYLFKG NNRWKQSIEL CKKDKLYKDA MEYAAESRNG ELAEELLSFF
LDEKLYDCFA ASLYHCYDLL HPDVIMELAW KHKIMDYAMP YMIQVMRDYQ TRLEKLERSE
HERKEEKAEQ QQNNGMTMEP QLMLTYGAPA PQMGYPGAPA GYGGQPAYGQ PGQPGFNAPG
FM
//
