ID A0A2G5UN46_9PELO Unreviewed; 1254 AA.
AC A0A2G5UN46;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=PIN domain-containing protein {ECO:0000259|SMART:SM00670};
GN Name=Cni-smg-6 {ECO:0000313|EMBL:PIC41005.1};
GN Synonyms=Cnig_chr_III.g8573 {ECO:0000313|EMBL:PIC41005.1};
GN ORFNames=B9Z55_008573 {ECO:0000313|EMBL:PIC41005.1};
OS Caenorhabditis nigoni.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=1611254 {ECO:0000313|EMBL:PIC41005.1, ECO:0000313|Proteomes:UP000230233};
RN [1] {ECO:0000313|Proteomes:UP000230233}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JU1422 {ECO:0000313|Proteomes:UP000230233};
RA Yin D., Schwarz E.M., Thomas C.G., Felde R.L., Korf I.F., Cutter A.D.,
RA Schartner C.M., Ralston E.J., Meyer B.J., Haag E.S.;
RT "Rapid genome shrinkage in a self-fertile nematode reveals novel sperm
RT competition proteins.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIC41005.1}.
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DR EMBL; PDUG01000003; PIC41005.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G5UN46; -.
DR STRING; 1611254.A0A2G5UN46; -.
DR Proteomes; UP000230233; Chromosome iii.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR CDD; cd09885; PIN_Smg6-like; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR018834; DNA/RNA-bd_Est1-type.
DR InterPro; IPR019458; Est1-like_N.
DR InterPro; IPR045153; Est1/Ebs1-like.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR002716; PIN_dom.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR15696; SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7; 1.
DR PANTHER; PTHR15696:SF40; TELOMERASE-BINDING PROTEIN EST1A; 1.
DR Pfam; PF10374; EST1; 1.
DR Pfam; PF10373; EST1_DNA_bind; 1.
DR Pfam; PF13638; PIN_4; 1.
DR SMART; SM00670; PINc; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000230233}.
FT DOMAIN 1064..1233
FT /note="PIN"
FT /evidence="ECO:0000259|SMART:SM00670"
FT REGION 1..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 273..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1025..1053
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..89
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..302
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..332
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..410
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..447
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1254 AA; 142226 MW; 75DB7DDA911DA922 CRC64;
MNGDTTTSEA PPPPTTKTRK PRPEIQIYRP GALRQGSGST KNLSTNDDRP PRPEKLTTSS
GNNSRRRSND TDSVTSRGGS GSTTPDAMAM NERGRNRFEG RGGAGGNSNY NSTQSLYDTR
QHGGYMEYNG SSGGAHGNRS NHHRNGGGGR FQNPNPNYHR NQQNQQSQPF ERNYQSSRGF
SERASMRGDG AIARRPQTTS RRQRNDSINS TQSEMPANNT QLHIDTSFDS ASQCGASSNF
SMNSLGEAFS FEEMCQNLQN FASMDWSKEV ENEFAMQKEL EEEEERQQAA EEAEMARKTT
QERRSPRKNR RNRRNYDESD RESSFGGSIA EEKEPEDDPE EELKSGERTP TSIRSGSSYN
PRVMYQKSRA ATNDENHHGR RQKENLSTKK EAPRRYRGEH DDRDDDTTEY SSLETSNTGR
LAGRITIVPR NREQEQNRNH RKTSADESSQ QQRQFYQKRS EKAQSEMVNR AEINRRRQEE
IDKNEGLRIR EIGEKMDKLS GAVKKRDLKS AERISEFSME LANIYSKLIL EDVIYSFTAG
LEQKLFRQAF YKSIECLRSG ANSASPDARL IRAATQKLLL NGILFYETLI SKYEQQFQLT
LADVLTWQSG FPTDEQLCST ALDLPIGSQK FESATQKTAI KSLSRHLISL GDLHRYKSLI
DGSENYEISK SYYQKSSQLW PSTGHPYNQL GIVVYYSMLY RSARRARLVP VDVLSKQRQK
RVIDEFFYLS RALACSHPYE AARDRLKQRL DAMRTKISKY QPVLDKECGI VKEQGNALRK
LQMIQQIWIH PTTESTEYGT GEKVVDDVLS HFMTHSKAKL HRRAVSYLCD TFGLLFTKIG
MEHFENVSER AFGLLYAALA KEEIDFEADQ LVKLAVMFIF VVQTNFEKAS TSSESTSQLQ
ISANTLCTYF HILREHMPRH RDLIFPAINV IATWIRNDAT EEILKTLGHH LETLTSSILP
NFQGFPSFSE DGIPELSENQ VYPEAVLLAS FFKIFDAVPT AATSSRVENL KLAVEKFRIL
AERTENSEEK TSKIERNSEE PKSREQMIEE ERDKGKGTIL IHPEYLIPDT NVFVGELQLV
KEILEMAQTA KKFQILVPTI VLDELQSISK LSPTDSKSQS EQHDPDRISK AKTAVNWLKE
QSKLKTPNLY TLTTTGKRLA SLLMAAEDLS GTGKMTNDDM ILNSALRWSE SLPLPSQNSI
LQNVATTTSL TSSESAVFLR NCVLITGDRG LTIKAIGNNL PCRGIANFVK WMRC
//
