ID A0A2G5UX58_9PELO Unreviewed; 3319 AA.
AC A0A2G5UX58;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=PLAT domain-containing protein {ECO:0000259|PROSITE:PS50095};
GN Name=Cni-lov-1 {ECO:0000313|EMBL:PIC44093.1};
GN Synonyms=Cnig_chr_II.g4581 {ECO:0000313|EMBL:PIC44093.1};
GN ORFNames=B9Z55_004581 {ECO:0000313|EMBL:PIC44093.1};
OS Caenorhabditis nigoni.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=1611254 {ECO:0000313|EMBL:PIC44093.1, ECO:0000313|Proteomes:UP000230233};
RN [1] {ECO:0000313|Proteomes:UP000230233}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JU1422 {ECO:0000313|Proteomes:UP000230233};
RA Yin D., Schwarz E.M., Thomas C.G., Felde R.L., Korf I.F., Cutter A.D.,
RA Schartner C.M., Ralston E.J., Meyer B.J., Haag E.S.;
RT "Rapid genome shrinkage in a self-fertile nematode reveals novel sperm
RT competition proteins.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIC44093.1}.
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DR EMBL; PDUG01000002; PIC44093.1; -; Genomic_DNA.
DR Proteomes; UP000230233; Chromosome ii.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR046791; Polycystin_dom.
DR PANTHER; PTHR10877:SF195; POLYCYSTIC KIDNEY DISEASE 1 LIKE 2A-RELATED; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00308; LH2; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR PROSITE; PS50095; PLAT; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000230233};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..3319
FT /note="PLAT domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013955995"
FT TRANSMEM 2367..2387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2576..2595
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2618..2640
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2668..2690
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2710..2734
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2796..2817
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3067..3087
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3116..3136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3167..3185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3205..3230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3266..3292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2410..2533
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT REGION 230..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 266..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 360..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 629..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 694..725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 845..950
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1070..1337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 845..948
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3319 AA; 356432 MW; F1286083AC1EC093 CRC64;
MEKFWLFVWL IALSVRSATS TLSYRNENGI AKFQTNDPGI TIQGVTRNTD GFIHVKLVCG
LNRLKIGNKD SEDVSLELIH NCIESEQRLV GLYLNSSWVP LSEVKDDDEV SIQVEAKYKK
CYEKGNVDAC DNSLWWLRAD GFETAKIDTW KSCESGDIEF LNQQRVCRRP YQSHGSTAIS
NQYGEYYDGQ VLKGYKAKKF VLELPEQQQT LVRQRVKRAT GDDKNVCDYT LDSTSTSTTT
PSTTTATTTV KTSTVTTSVI TSTASSSTTV LTSTQSSSTQ STSTPSTSTV MSSTGSTSTA
AQSTSTSKAA SSSTTTLSTS VKPSTSTPKS TSTAVPTTVT TLPPNAICSY LDETTTSTTF
STTITSTTTE PSTSTESTSV STSQSTSTPS TSTVTTSTTA PTSTTIASTS TSAPTSSTTV
TTQSTSVSTS TAVPSTSTTV TPSTSSASTS ASTSASTSAS STASTSTSAP TSTGPTTGTT
SISSSFSTSS TGASSSTTVV TTPTTTVSTS QGSTTTPLDS TTFEFKNKSL TVDDGDDLVE
LALVTNVPLG EYTTQWMCKS GDGEYQLTNV AGVCFKEGYN PPLQGANRSA SLFAGPGTYT
FLATMIKNDG SRYNATMVLT IVGTTTIGES TVTSSGTSSG ISTGTSTTTQ SSSTSSVSSS
TSPITSSTTV VTSTTRPTSS AATTTVFSST TLKDVTTSDS GASPSFSSEA TTDSSSTSSD
SKTTSTTDFD FILSNDLPWT KTVYFTDTVN IVPVPTISLD PIYQNVTFEC RSDASEEFVT
VKQSTCLNQE QQIVRMASFS KNINLEPVSE FVVGLGTFEF RINMTNTQTN QMASHAFTLN
VVGETSSTEE VVTTTMATST TSESSSTAEK STTEIAEPTS TTSNDDSTTS NDGPDSSTTT
SVGSESSTTS DSGDSGDSTT TSLDLSDSST SPTTIDPDSM STTIDPDATT PIPYDFILTD
LSWNETITYS EDPLTISPVP NKNPGLIDTA ISYQCRNDSS KPFVSLKESD CLTDTGKVGS
YSGAITFDPF SSFVPGSGVY EFLINCTNRV TSESASHVFT MNVVLPTTPT EYVPTEASSD
STGGSSDSSR ASGPTGTTTS SGGSGVTTSV DSDGSGGSTT DSSSGSKTTS GSDSQGSSTL
SGDSKGSSTL DPLAGVTTID PSGGSTSSGR STTKDSSGSG SSTTSGSDDG SATTSVDSLL
GVTTSGQGSV TTTGSGSGAT TTVGSGGTGT TTGSGESGSA TTASNFGSES TTLGGSGGST
SPGSGDGTTQ SDGSQGSTTG GPGSDGSQGS TTGGPGSEGS TTGGAGSDSD ASTAYSGPST
TTQGSTKTTR KRGSLPTLTP ISAADQAAID AQKADVMSQL AGIMAGASSG SSLNSSSSLL
NQISSLPASD LVEVAQSLLS NTLKIPGVGN MTSVEVLQTL QNNIATTNSE LAAEMTKVIT
QLANVNMTSP QSMNSVLSSL DLALKGSTVY TLGVSSTKST DGTYAVIFGY VLASGYTLVS
PRCTLSIYGT TVYLTGDTRA SYKQLEGDTV TATSLLASAL GIEGSYATNG RTVSVDQDKI
EQKRSLVSGN IMATVNGIGD VQSGEYTYNE MYVTAWNVTY DNTTTGSTPQ KNTSMSFYIP
VSDAQLTLLI ESGTMMKLQS TQTVAAKGLT VTTTYGGVTY TVTCGNGTAK FVEVDTADAI
FSYNAPSFEV VAADGSSTAS IQKMIQMPIV VENVNLNVFN KTSSPLVFSA AGSYTMRLVF
SPQDIDLPAV SALSQTVSIS TLSPTTTYSK TDLQTAISSQ SMISVSGTLF FAKASSIDVT
GYTFYADSTA IYLQNSVSTV VISSPTYNVV ALALGGYGIQ ITAGTYTSGS QSHTVTMMEF
SDTQKMRIDG GLVIRNGTNG YVIQNGQITT EGDVSGTQID IVPQSLMNQE SQEQIAQILS
NTQDYLQNNG MTMTEAEIND TSNSLLSIAS SLTSALKVAL DNPLSSDLAA NLKYATDNYD
DLYNVLPSDP DNIVYVEEMT QEEWAAYVTK MIQKNIAKNL ATQLASTLDT LENTLAARAI
AEGNLPYDYS NYVDGTGMVI VIDDASNIVG KTQTCSEWAM TLPSPASSLN NAEIQDSTLI
QVGMVCYNTN PRTYVDNFDM LVTSGALEAH IKDEYQNQLK IINSTSPILV NGRGSSDDAV
LTLMQQGDFV SYQILDLHAF QTTNWNNSLQ LEVIASQDYV IPNNDDTYLF SAFQHLPGPM
YSNYEWMFDL NSLNTTSNYF ITAGNLINQT GLFYVGIGKR NETTSTNENS TDIVNYGTFD
NKQWSFAREV PMDYQITAIS KGCYFYLNET DMFNSAGMWP LDGKGMQFVN CSTDHLTLFS
VGSFNPTIDA DFHYKYVVNE IEKNVKVMIT AIFLFIVYGC LTLNSIISGR KDASKGRLRF
LSDNEPHDGY MYVIAVETGY RMFATTDSTI CFNLSGNEGD QIFRSFKSVE DGDWEYPFSW
GTTDRFVMTT AFPLGSLEYM RIWIDDAGLD HRESWYCNRI TVKDLQTQEI YHFPFNNWLG
TKNGDGETER LARVDNKRRF LDESMSMHML AQTISWFAMF TGGGNRLRDR VTRQDYSISI
IFSIVMICIL SIVILRNDDS IISDSKSISE FTFTVKDIIF GIVFALLITI INTFHILLCI
KSRSYSEHYY LKKRKHEEPT FKDPSGSWSV FVAGIARALL AFPVLMGLLY VAGDGMSLMD
DFANAFYIRF LISLVVWAVV FEPIKGMIWA FFILKTSKSH KITNKLEEAF LKVKPAETFQ
RNPYGKIEKE LGTVIADVTK LRDTENRKMR DEQLFITIRD MLCFFASLYI MVMLTFYCKD
RHGYYYQLEM STILNIPQTN YGDNTFMSIQ NADDFWDWAR DSLATALLAS WYDGNPAYGM
RAYLNDKVSR SMGIGTVRQV RTKKSAQCEV VKQFKDYINN CGEELTEDNE ETTLYMQPGW
TELETENGTD ATDEYTYKTA KELSTSSVSG FLGSYGGGGY TVSMSGTQAD IIALFNKLDK
ERWIDDSTRA VIIEFSAYNA QINYFSVVQL VVEIPKSGIY LPNSWVESVR LIKSEGSDGT
AVKYYEMLYI FFSVLIFVKE VLFYIYGRYK VITTMKRTLN PFKIVYKLVL GEFSPWNFMD
LVVGALAVAS VFAYTLRQKY TNHAMEDFNA KNGNAYINLT IQRNWEITFS YCLAGAVFFT
SCKMIRILRF NRRIGVLAAT LDNALGAIVS FGVAFLFFCM TFNGVLYVVL GNKMGGFRSL
ISTFQTSLAG MLGKLDVVSV QPISKFAFVV TMIYMIVGSK LVLQLYVTII MFEFEEIRND
SEKQTNDYEI LDHIKYKTF
//
