ID   A0A2G5UY59_9PELO        Unreviewed;       186 AA.
AC   A0A2G5UY59;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   24-JAN-2024, entry version 14.
DE   RecName: Full=Calcium load-activated calcium channel {ECO:0000256|PIRNR:PIRNR023322};
DE            Short=CLAC channel {ECO:0000256|PIRNR:PIRNR023322};
GN   Name=Cni-F22B5.10 {ECO:0000313|EMBL:PIC44430.1};
GN   Synonyms=Cnig_chr_II.g4799 {ECO:0000313|EMBL:PIC44430.1};
GN   ORFNames=B9Z55_004799 {ECO:0000313|EMBL:PIC44430.1};
OS   Caenorhabditis nigoni.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=1611254 {ECO:0000313|EMBL:PIC44430.1, ECO:0000313|Proteomes:UP000230233};
RN   [1] {ECO:0000313|Proteomes:UP000230233}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JU1422 {ECO:0000313|Proteomes:UP000230233};
RA   Yin D., Schwarz E.M., Thomas C.G., Felde R.L., Korf I.F., Cutter A.D.,
RA   Schartner C.M., Ralston E.J., Meyer B.J., Haag E.S.;
RT   "Rapid genome shrinkage in a self-fertile nematode reveals novel sperm
RT   competition proteins.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Calcium-selective channel required to prevent calcium stores
CC       from overfilling. {ECO:0000256|PIRNR:PIRNR023322}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the TMCO1 family.
CC       {ECO:0000256|ARBA:ARBA00006537, ECO:0000256|PIRNR:PIRNR023322}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PIC44430.1}.
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DR   EMBL; PDUG01000002; PIC44430.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2G5UY59; -.
DR   STRING; 1611254.A0A2G5UY59; -.
DR   Proteomes; UP000230233; Chromosome ii.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IEA:UniProtKB-UniRule.
DR   InterPro; IPR002809; EMC3/TMCO1.
DR   InterPro; IPR008559; TMCO1.
DR   PANTHER; PTHR20917:SF0; CALCIUM LOAD-ACTIVATED CALCIUM CHANNEL; 1.
DR   PANTHER; PTHR20917; PNAS-RELATED; 1.
DR   Pfam; PF01956; EMC3_TMCO1; 1.
DR   PIRSF; PIRSF023322; DUF841_euk; 1.
DR   SMART; SM01415; DUF106; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRNR:PIRNR023322};
KW   Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW   ECO:0000256|PIRNR:PIRNR023322};
KW   Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR023322};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|PIRNR:PIRNR023322};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR023322};
KW   Reference proteome {ECO:0000313|Proteomes:UP000230233};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR023322}.
FT   TRANSMEM        6..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        88..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   COILED          33..86
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   186 AA;  21179 MW;  F28943A97D873346 CRC64;
     MLADCLLIIG IAFGTALAGE GITWLLVYRS DQYKRLKADM DKKTKKLEKK KQEVGDTNDK
     NIKKKLEREE EKLKATNRDM SMFKMKSMFA IGLAFTALLS TFNSIFDGRV VAKLPFYPIG
     FIQGLSHRNL IGDDMTDCSF IFLYILCTMT VRQNLQKILG FAPSRAMARQ QSSPWAPPSS
     QMNYLR
//