ID   A0A2G5V273_9PELO        Unreviewed;       923 AA.
AC   A0A2G5V273;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   08-NOV-2023, entry version 17.
DE   RecName: Full=DH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   Name=Cni-ect-2 {ECO:0000313|EMBL:PIC45892.1};
GN   Synonyms=Cnig_chr_II.g5762 {ECO:0000313|EMBL:PIC45892.1};
GN   ORFNames=B9Z55_005762 {ECO:0000313|EMBL:PIC45892.1};
OS   Caenorhabditis nigoni.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=1611254 {ECO:0000313|EMBL:PIC45892.1, ECO:0000313|Proteomes:UP000230233};
RN   [1] {ECO:0000313|Proteomes:UP000230233}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JU1422 {ECO:0000313|Proteomes:UP000230233};
RA   Yin D., Schwarz E.M., Thomas C.G., Felde R.L., Korf I.F., Cutter A.D.,
RA   Schartner C.M., Ralston E.J., Meyer B.J., Haag E.S.;
RT   "Rapid genome shrinkage in a self-fertile nematode reveals novel sperm
RT   competition proteins.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PIC45892.1}.
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DR   EMBL; PDUG01000002; PIC45892.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2G5V273; -.
DR   STRING; 1611254.A0A2G5V273; -.
DR   Proteomes; UP000230233; Chromosome ii.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:2000431; P:regulation of cytokinesis, actomyosin contractile ring assembly; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 3.40.50.10190; BRCT domain; 2.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR026817; Ect2.
DR   PANTHER; PTHR16777; PROTEIN ECT2; 1.
DR   PANTHER; PTHR16777:SF2; PROTEIN ECT2; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00292; BRCT; 2.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF52113; BRCT domain; 2.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000230233}.
FT   DOMAIN          115..201
FT                   /note="BRCT"
FT                   /evidence="ECO:0000259|PROSITE:PS50172"
FT   DOMAIN          207..294
FT                   /note="BRCT"
FT                   /evidence="ECO:0000259|PROSITE:PS50172"
FT   DOMAIN          363..561
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          304..333
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          891..923
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   923 AA;  105818 MW;  2FFEAA56972D0E34 CRC64;
     MDVSMLSPQK RSRNIQKLAV WRGDVAQNKE MFDWLEEQKE KRKIEVVYYE NLEELDSDWS
     EYTFFCGDFK SDLFRKLTQN QDTGTSAHLI VGTAVLKQKL KRRLDFMPLR PCRPLYCELM
     KNVTMKLSTE VTNKRELVEL VHFMGGSVRK DTVQRTNVFI AAKVEAKVQS MTLVGVPTLR
     ADWITDCWEN RDDPDYDVFR QDIVDKHKLG VFEGLSLYFH GFKKNEIDDM CFNLNNTGGT
     LAEDPSKATH VVYNPVNDDV ETLPVSANQV HVTQEWFWVS LHRGWCALED NFALPSGTLR
     RKPLDNSTIN SPLGKSLRSH NSRSLSSMRD CSGEGPSLNM TPDYIYSNDE VENVGKSPRQ
     PSKRLRVCME MVDTERNYVS LLKLVIKFKE ALEKEIAQNE FMTKSDVAMM FGKLDPILEL
     HEKIHAKLSS IMAEANSVLT AANGKKNDDK SLDFAQVWID AKDEMKKAYP QYINSFDTMK
     RFFDKQDREN SKFHTFCKAK ESNPEFHRLK LTDLMVKPVQ RLPSVALLLK EIGKKSESKL
     KHTAEEAQKV IDEVLKVANK TREKNDNLIS HLSKFTDIEN VPPTLVAANR MFCRELVVSP
     IASTSSRLSV VPRMKLFFFH DVLILTKIRS EKNTMQRLAR HASFASLHAR QRRPYKYIDQ
     IQLTTMRSAF RIRPPEEVSK FLEAHHTVHG IRPREVFVWC LIHRDEQGGD TETVFESSDC
     EEVRDFLDEI HLKLMSNCGR FFFQTEMADV NELNDAHVAD MTTRFFKNLC ATKPQTGHGS
     QMNITEWSHN ESMMGPPQSQ SRMRRAFSNA QLTITSTLGF GRNQSRNNLA RINENSSFMA
     SPRVSCDPAA LANMTSVGMP GSVSESESTP KRGLRARLTS STFLNRTHLV RNSSMRRQTH
     GFASQSEIEP ARSRTSSQRV TDL
//