ID A0A2G5V4U3_9PELO Unreviewed; 1422 AA.
AC A0A2G5V4U3;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=Cni-clr-1 {ECO:0000313|EMBL:PIC46798.1};
GN Synonyms=Cnig_chr_II.g6376 {ECO:0000313|EMBL:PIC46798.1};
GN ORFNames=B9Z55_006376 {ECO:0000313|EMBL:PIC46798.1};
OS Caenorhabditis nigoni.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=1611254 {ECO:0000313|EMBL:PIC46798.1, ECO:0000313|Proteomes:UP000230233};
RN [1] {ECO:0000313|Proteomes:UP000230233}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JU1422 {ECO:0000313|Proteomes:UP000230233};
RA Yin D., Schwarz E.M., Thomas C.G., Felde R.L., Korf I.F., Cutter A.D.,
RA Schartner C.M., Ralston E.J., Meyer B.J., Haag E.S.;
RT "Rapid genome shrinkage in a self-fertile nematode reveals novel sperm
RT competition proteins.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIC46798.1}.
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DR EMBL; PDUG01000002; PIC46798.1; -; Genomic_DNA.
DR STRING; 1611254.A0A2G5V4U3; -.
DR Proteomes; UP000230233; Chromosome ii.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 1.
DR CDD; cd00047; PTPc; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR19134:SF495; TYROSINE-PROTEIN PHOSPHATASE 69D; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00409; IG; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 4: Predicted;
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000230233};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1422
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013962741"
FT DOMAIN 61..102
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 159..269
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 373..503
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 796..1075
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 995..1066
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1144..1414
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1328..1405
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 646..683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 651..683
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1422 AA; 160748 MW; 30ADB50FFE4C22D7 CRC64;
MRINRWIWWT TVILLYLRTE LLQAADLFRS SEENEKAKDN IDNWNSTKIE PEKPKNAKEL
GVHVCESNQD CVNGGVCHRG KDGHGICLCP RSCPSFVPPR CGNRRAAAPC LVMDKDYRSK
YDLRDPTCYM NGCVCPPQFD TVHVTADQKP LRLNSTLLPT KCDKRDLAVV GRVHPSLSVF
KGIDVTMFCC VNLDPEGFID VANVFFIQNG TLMREPTSHP FSPSTRGGIA RRVHEKQSCW
ELEIKNVQTS DSGTYMCRVT ASAPDLDVTD TMQFEVKAPR QISKLNVTAS ERDAIVTWES
EGEEMAIDLR LVRRSDTRGA VVYRGDNVTS PVVVKDLRAA TPYTLFASGK DGSVPFELTH
HFTTGQKRPF PPKEEDVRIL NSGSSLSCEV EWKTPAETNG RITKYFVSVR GAMRKSDGTL
TPDDFPSAEE VDKRCANWDE DESKSAQNGI NPIDFSNDFY SCKFGPLKPN RNYSVSVWAE
NSAGRSLPAV FKKNCVTNFA QPDLVETPQT LRTANMTTFN LAFSHPPDDM NGPISCYYIA
IVPLPTNVSL DLLPETNEIV MDSFTKVYAN NLHSSAAEKK RFFAYVAESY TELPMETVIG
DGLGVSGLKA CNVRYLSRYT AEDLALRNGL KYTGFLIVRV DKEEELNRKG GPSGTNGSSI
YRNLIDKSSP TTERSRTSSS ATRHLRQLHL SGPAYGYSGY FKPILLDSNS SSGGYGVFVK
IVLPILIFLV CATCLSLFMI NRKNQFLSDW CPPFISKMAS KDVVERTLLK QTFGAIPVED
LPTEYVTRHR DSDFLFVQEY EALPHFPMNT VASNRKENAI KNRYNDIRAF DETRVKLEQI
GGDEHSDYIN ANFIKSWKEK KLFIAAQAPV EATIDDFWRM IWEQKSELIV MVANLTEKNR
QQCAKYWPDE EISRYGDIIV EPTSVSFHSD YVVRKFDIAH IAECGPDVIL NENGVEYANV
PIVKGQFAEN ARHILQYHFT NWNDYKAPEC STGLLRFMYI LRELPEFNNS PVVIHCSAGV
GRTGTFITID SMFDQCLAER KANVFEFVCN LRRQRNLMVQ SVEQYVFIYK ALAEWHMYGY
TDMDVADFEE HYQRLLCEST AASSSRDRAV SFNQSSSGNG SISTRVAIVS SRESILTSNS
ETGLEEEFKK LERNLATGLP TSFASKDENL LKNRYEAAVP YDKYRVILPP TIGHADSSYI
NASHIKGYFY DYIAAQDPVG TSSSTVFDFW RMIADQKVTT VVMLSDENDW SDSEKYWPIE
GPGTDCHFQE GRNAIDVACV SLEQHQDFVV RHLTYTMKNA DSTSPIQDLT QYSYTAWPTD
ALVPRSPNSL MNLISLVLQR QSNLLESRAP IVVHCRNGSS ETGIFICISL LMLRQKAEQR
IDIFQTVKGL QSHRPMMFTR FEQYSFCYRA LADYISQTLL LR
//
