ID A0A2G5VDC9_9PELO Unreviewed; 602 AA.
AC A0A2G5VDC9;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 08-NOV-2023, entry version 12.
DE RecName: Full=Biopterin-dependent aromatic amino acid hydroxylase family profile domain-containing protein {ECO:0000259|PROSITE:PS51410};
GN Name=Cni-cat-2 {ECO:0000313|EMBL:PIC49774.1};
GN Synonyms=Cnig_chr_II.g8271 {ECO:0000313|EMBL:PIC49774.1};
GN ORFNames=B9Z55_008271 {ECO:0000313|EMBL:PIC49774.1};
OS Caenorhabditis nigoni.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=1611254 {ECO:0000313|EMBL:PIC49774.1, ECO:0000313|Proteomes:UP000230233};
RN [1] {ECO:0000313|Proteomes:UP000230233}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JU1422 {ECO:0000313|Proteomes:UP000230233};
RA Yin D., Schwarz E.M., Thomas C.G., Felde R.L., Korf I.F., Cutter A.D.,
RA Schartner C.M., Ralston E.J., Meyer B.J., Haag E.S.;
RT "Rapid genome shrinkage in a self-fertile nematode reveals novel sperm
RT competition proteins.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954,
CC ECO:0000256|PIRSR:PIRSR601273-2};
CC -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
CC hydroxylase family. {ECO:0000256|ARBA:ARBA00009712}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIC49774.1}.
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DR EMBL; PDUG01000002; PIC49774.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G5VDC9; -.
DR STRING; 1611254.A0A2G5VDC9; -.
DR Proteomes; UP000230233; Chromosome ii.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0016714; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen; IEA:InterPro.
DR GO; GO:0009072; P:aromatic amino acid metabolic process; IEA:InterPro.
DR Gene3D; 1.10.800.10; Aromatic amino acid hydroxylase; 1.
DR InterPro; IPR001273; ArAA_hydroxylase.
DR InterPro; IPR018301; ArAA_hydroxylase_Fe/CU_BS.
DR InterPro; IPR036951; ArAA_hydroxylase_sf.
DR InterPro; IPR036329; Aro-AA_hydroxylase_C_sf.
DR InterPro; IPR019774; Aromatic-AA_hydroxylase_C.
DR PANTHER; PTHR11473; AROMATIC AMINO ACID HYDROXYLASE; 1.
DR PANTHER; PTHR11473:SF15; TYROSINE 3-MONOOXYGENASE; 1.
DR Pfam; PF00351; Biopterin_H; 1.
DR PRINTS; PR00372; FYWHYDRXLASE.
DR SUPFAM; SSF56534; Aromatic aminoacid monoxygenases, catalytic and oligomerization domains; 1.
DR PROSITE; PS00367; BH4_AAA_HYDROXYL_1; 1.
DR PROSITE; PS51410; BH4_AAA_HYDROXYL_2; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR601273-2};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR601273-2};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000230233}.
FT DOMAIN 251..597
FT /note="Biopterin-dependent aromatic amino acid hydroxylase
FT family profile"
FT /evidence="ECO:0000259|PROSITE:PS51410"
FT BINDING 430
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT BINDING 435
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT BINDING 475
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
SQ SEQUENCE 602 AA; 68149 MW; 79E38E021318DC5A CRC64;
MMIIGRKPMC SVYSRKEQQL SVSQDEDEEW EKEIFLGRWG GAITLFWIGY KFTTVTLTPL
FQKLSSPLAK LIAAVNVARN VSINMSSLTN PTNTVMEEEE NPVAAPIQRG NKNPRRYSLV
HQASCETQHH IGIRRQNTIQ HRKQLTDQMR GQKILQQLND EGVEVIFAAN DVSSIDFSVI
VTSTDYISTF VSDILYNMKS AGVQICHVET RESKTVSGHD VLLDCRATKN QLIQAAELLT
QNHVALTHFS IFSKKSVEKS QSMIWFPRHI SELDQCSKCI TKYEPTTDPR HPGHGDEEYI
ARRKFLNDQA LEFKFGDEIG YVEYTEDEHA TWKAVYEKLG GLHESHTCGV YRQNLKILQK
EKVLTADRIP QIRDVNKFLQ KKTGFELRPC SGLLSARDFL ASLAFRVFQT TTYLRHHKSP
HHSPEPDLIH ELLGHVPMFS DPLLAQMSQD IGLMSLGASD EHIEKLATVY WFIVEFGLCK
EDGKLKAIGA GLLSAYGELI HACSDAPEHK DFDPAVTAIQ KYEDDDYQPL YFVADSIHDA
LAKLRKYASS MDRPFSVVYD PFTKSIETIQ SSADLEKAFS RLSNDLSAIT HAADRMKISI
AA
//
