ID A0A2G5VHQ7_9PELO Unreviewed; 849 AA.
AC A0A2G5VHQ7;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=DNA mismatch repair proteins mutS family domain-containing protein {ECO:0000259|PROSITE:PS00486};
GN Name=Cni-msh-2 {ECO:0000313|EMBL:PIC51339.1};
GN Synonyms=Cnig_chr_I.g1889 {ECO:0000313|EMBL:PIC51339.1};
GN ORFNames=B9Z55_001889 {ECO:0000313|EMBL:PIC51339.1};
OS Caenorhabditis nigoni.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=1611254 {ECO:0000313|EMBL:PIC51339.1, ECO:0000313|Proteomes:UP000230233};
RN [1] {ECO:0000313|Proteomes:UP000230233}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JU1422 {ECO:0000313|Proteomes:UP000230233};
RA Yin D., Schwarz E.M., Thomas C.G., Felde R.L., Korf I.F., Cutter A.D.,
RA Schartner C.M., Ralston E.J., Meyer B.J., Haag E.S.;
RT "Rapid genome shrinkage in a self-fertile nematode reveals novel sperm
RT competition proteins.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIC51339.1}.
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DR EMBL; PDUG01000001; PIC51339.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G5VHQ7; -.
DR STRING; 1611254.A0A2G5VHQ7; -.
DR Proteomes; UP000230233; Chromosome i.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF35; DNA MISMATCH REPAIR PROTEIN MSH2; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000230233}.
FT DOMAIN 713..729
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
SQ SEQUENCE 849 AA; 96354 MW; FBF586A1DED68E19 CRC64;
MSGGKDEASD KALLKILKKK SQNTIAIFSR GEYFTVYGDD ASFVATNIFK SDVCVKTFTL
CTNDSQQMKY ISVNRGQYEK VVRETVVLLR CSVEVFASEQ GEWKMIKRGS PGNTVEFEQE
IGVVDQAPVI AVYLHPGDND IRVTLCAWDS GNVRIVTSEF IDTSGFSQIE QCIFGLCPTE
YILVNGTASG PKVKKLASMF TKMEVHCKQQ MKQKSEWNDV LECIHQDYRE EAEKQSDQVK
ECLQILHANV ADEYSHSEKY SIFNYGTHGN MQIDSCAVEA LELFQLNYNY LEKSNNLTLY
NVLNKCKTLP GEKLLRDWLS RPLCNVDHIN ERLDVVEALS ENQTIRQKLH DSFLARMPDC
SQLARRLMRK CTLQDLNRFY QASTLLESVE LQLIHLSEDE RFSASIDRLL KSEVTSILKK
VERFLVLCDE FFDFDYEKEH KEIRVRVDFV PEIQEISEKL EQVEKIAEKL RKKYSSKFEC
ENMKLDKNSQ YGYYFRVTLK DEKAIRKKDV QILETTKGSG VKFTVSDLTE INDEFLEYHV
KYTRAEEEVI SMLCKKAEEF IPLIPAMAQI ISTLDVFVSL ATFCSMSSGM YVRPQLLPLG
SKCLELKQCR HPVIERNSEK PFIPNDVVLK ENRLIVLTGA NMGGKSTYLR SAALSILLAQ
IGSFVPCSSA LISVVDGIFT RVGASDKQSQ GISTFMAEML DCSAILQRAT ENSFVVIDEL
GRGTSTFDGF GIASAIAQDI LNRIKCLCIF ATHFHEMGKL AEQPGAIALQ MGVQIENNQI
HMLYKVFEGI AQRSFGLQVA KMVGLDEDVI NKASQLLENL EKKVIIDSEK KKELLESSDI
RQSILRLIN
//
