ID A0A2G7GB79_9EURO Unreviewed; 1458 AA.
AC A0A2G7GB79;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Multidrug resistance protein CDR1 {ECO:0000313|EMBL:PIG90108.1};
GN ORFNames=AARAC_001941 {ECO:0000313|EMBL:PIG90108.1};
OS Aspergillus arachidicola.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=656916 {ECO:0000313|EMBL:PIG90108.1, ECO:0000313|Proteomes:UP000231358};
RN [1] {ECO:0000313|EMBL:PIG90108.1, ECO:0000313|Proteomes:UP000231358}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 117610 {ECO:0000313|EMBL:PIG90108.1,
RC ECO:0000313|Proteomes:UP000231358};
RA Moore G., Beltz S.B., Mack B.M.;
RT "Genome sequence for an aflatoxigenic pathogen of Argentinian peanut,
RT Aspergillus arachidicola.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG family.
CC PDR (TC 3.A.1.205) subfamily. {ECO:0000256|ARBA:ARBA00006012}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIG90108.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; NEXV01000020; PIG90108.1; -; Genomic_DNA.
DR STRING; 656916.A0A2G7GB79; -.
DR OrthoDB; 5473955at2759; -.
DR Proteomes; UP000231358; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03233; ABCG_PDR_domain1; 1.
DR CDD; cd03232; ABCG_PDR_domain2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR029481; ABC_trans_N.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR043926; ABCG_dom.
DR InterPro; IPR034001; ABCG_PDR_1.
DR InterPro; IPR034003; ABCG_PDR_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010929; PDR_CDR_ABC.
DR PANTHER; PTHR19241:SF498; ABC TRANSPORTER PROTEIN; 1.
DR PANTHER; PTHR19241; ATP-BINDING CASSETTE TRANSPORTER; 1.
DR Pfam; PF01061; ABC2_membrane; 2.
DR Pfam; PF19055; ABC2_membrane_7; 1.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF14510; ABC_trans_N; 1.
DR Pfam; PF06422; PDR_CDR; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000231358};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 486..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 518..539
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 560..584
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 596..616
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 628..647
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 731..752
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1152..1172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1184..1206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1227..1253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1273..1295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1307..1330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1423..1444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 118..373
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 815..1058
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 61..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1458 AA; 164113 MW; 3B962B5AD0F8A289 CRC64;
MARPGEERSL HGHANTHVKQ TTGSAIDKAE SSDTIGADPE DGIEQDGQAK ITTLARTLSR
ISQTNGSTEG LNPFLNTNDP ELDPNSDQFN SRKWTKNLLH ITSRDPERYP RYGIKCLAQS
SGLAPSLFGN GNKVRIDILR NFEGFVNSGE MLVVLGRPGS GCSTFLKTIA GETHGLWIDK
GTDIQYQGIS WDEMHSRFRG EVMYQAETEI HFPQLTAGDT LLFAAKARAP ANRLPGVSRD
QYATHMRDVV MAMLGLTHTM NTLVGNEFIR GVSGGERKRV SIAETTLCGS PLQCWDNSTR
GLDSSTALEF VKNLRLSTDY TGSTAIVAIY QASQAIYDVF DKVIVLYEGR QIYFGRARDA
KRFFIEMGFD CPERQTTGDF LTSLTSPTER LVRKGYEHLV PRTPDEFAAR WRDSLERKQL
LADIQAFQNE FPLGGSKKEE FSRSRAAEKA KHTRASSPYT LSYLMQIKLC LQRGFLRLKG
DMSMTLSTVI GNSILALIIS SVFYNLNDTT DSYFSRGALL FFAILLNAFA SALEMLTLWQ
QRPIVEKHDK YALYHPSAEA ISSLIVDLPA KALVSVVFNL ILYFMTNLRR TPGHFFVFYL
FSVTTTLTMS NVFRWIAAVS RSLAQAEVPA SIFMMILMIY TGFTIPVRDM HPWFRWLNYI
NPIAYSFESL MINEFAGRKF HCATYVPSGP GYENAPLDSK ICSGKGAVAG QDYIDGDRYL
EVAFEYYPSH LWRNFGILLG FLFFSLVAYI VSSELVRAKP SKGEILVFPR GKIPAFAKKV
HQQADPEDVL TSEKLKVGNE QDDHVGAIVK QTSIFHWQDV CYDIKIKGQD RRILDHVDGW
VKPGTLTALM GVTGAGKTSL LDVLANRVTM GVITGEMLVD GRMRDDSFQR KTGYVQQQDL
HLETSTVREA LIFSALLRQP ASTPRKEKLA YVEEVIKMLN MEEYAEAVVG VLGEGLNVEQ
RKRLTIGVEI AAKPDLLLFF DEPTSGLDSQ TAWSICSLMR KLADHGQAIL CTIHQPSAIL
MQQFDRLLFL AKGGKTVYFG DLGPNMRTLI KYFEDKGSPK CPPNANPAEW MLEVIGAAPG
SRADQDWSDV WKHSRERSRV QQELLQMKQE LLQQPQPPRT AGYGEFAMPL WAQFFICLQR
VFQQYWRCPS YIYAKAAMCI IPPLFIGFTF WREPTSIQGM QNEMFSIFML LVIFPNLVQQ
MMPYFAMQRS LYEVRERPSK AYSWKAFMLA SIVVELPWNM LMAVPAYFCW YYPIGLFRNA
YPTDSVTERG GTMFLLVLIF MLFTSTFSSM MIAGIDHPET ASNIAQLMFS LCLIFCGVLA
SPDVLPRFWI FMWRASPFSY LVGSVLAVGI AGAPVHCSDI EVLHIPPPGG QNCSGYLEAF
TKMAKSTLLN PEADSDCQVC SLSTTDQFLA GVHIKYSELW RNVGILFVYI VFNTVAAVFL
YWLIRVPKKR ALKKAKKE
//
