ID   A0A2G8EHY9_9GAMM        Unreviewed;       684 AA.
AC   A0A2G8EHY9;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   Name=helD {ECO:0000313|EMBL:PIJ74142.1};
GN   ORFNames=BK416_05100 {ECO:0000313|EMBL:PIJ74142.1};
OS   Erwinia sp. OLSSP12.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Erwinia.
OX   NCBI_TaxID=1912096 {ECO:0000313|EMBL:PIJ74142.1, ECO:0000313|Proteomes:UP000229786};
RN   [1] {ECO:0000313|EMBL:PIJ74142.1, ECO:0000313|Proteomes:UP000229786}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OLSSP12 {ECO:0000313|EMBL:PIJ74142.1,
RC   ECO:0000313|Proteomes:UP000229786};
RX   PubMed=29067021; DOI=10.3389/fmicb.2017.01969;
RA   Chen X., Hitchings M.D., Mendoza J.E., Balanza V., Facey P.D., Dyson P.J.,
RA   Bielza P., Del Sol R.;
RT   "Comparative Genomics of Facultative Bacterial Symbionts Isolated from
RT   European Orius Species Reveals an Ancestral Symbiotic Association.";
RL   Front. Microbiol. 8:1969-1969(2017).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PIJ74142.1}.
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DR   EMBL; MNCH01000011; PIJ74142.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2G8EHY9; -.
DR   OrthoDB; 5298826at2; -.
DR   Proteomes; UP000229786; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   CDD; cd17932; DEXQc_UvrD; 1.
DR   CDD; cd18807; SF1_C_UvrD; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR022161; Helicase_IV_N.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF63; DNA HELICASE IV; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF12462; Helicase_IV_N; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000229786}.
FT   DOMAIN          195..505
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   BINDING         216..223
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   684 AA;  78518 MW;  D70B00C344768654 CRC64;
     MELKSTSLGK HLARHPYNQV RLLNAGVEVS GEKHQYLIPF NQLLTIRCKR GVVWGELEFT
     LIDEKVVRLH GTEWNETQRF FHYLDKAWTR WSEEMSEVSA TVLADAVRVI DDVKQQSRWL
     KSSDITDLRQ QLDSLFSALP LPHQRLPQFA NCGQQWAYCQ CWYQQADEQR QQHNAQWSSR
     MLEEYADFFN TVESTPLNES QARAVVNGED AVLTLAGAGS GKTSVLVARA GWLIQRKLAN
     PEQILLLAFG RKAAEEMQQR VQQRLNKEEI DVRTFHSLAL HIIQQASQRP PAISVLETDA
     MKRREFLVSV WRQQCAEKKA QAKGWRQWLE EELGWTLDDA AFWQDERLAS RVASRLERWL
     GLMRTHGGAQ AAMIEQAPDA LRDQFSKRVR LMAPLVKAWK SALKNEGAVD FAGLIHQAVN
     LLDKGRFISQ WKAILVDEFQ DISPQRACLL AALRRQNTRT SLFAVGDDWQ AIYRFSGAEM
     ALTTAFHHHF GEGDRCILDI TYRFNERIGD IANRFVQQNP HQLKKPLNSL RKGSKKAVIL
     LPENQFEALL NKLSGFVRPQ EKVLVLARYH YLRPAELDKA KTRWPGLDIE FMTIHVSKGR
     QADYVILLGL SQGKEGFPAV ARESVIEEVL LPVPEDFPDA EERRLAYVAL TRAKEQVWLL
     FDPQAPSVFV DEFKRLGVSV QRKP
//