ID A0A2G8JCR1_STIJA Unreviewed; 530 AA.
AC A0A2G8JCR1;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=Importin subunit alpha {ECO:0000256|PIRNR:PIRNR005673};
GN ORFNames=BSL78_29657 {ECO:0000313|EMBL:PIK33523.1};
OS Stichopus japonicus (Sea cucumber).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK33523.1, ECO:0000313|Proteomes:UP000230750};
RN [1] {ECO:0000313|EMBL:PIK33523.1, ECO:0000313|Proteomes:UP000230750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Shaxun {ECO:0000313|EMBL:PIK33523.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PIK33523.1};
RX PubMed=29023486;
RA Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT "The sea cucumber genome provides insights into morphological evolution and
RT visceral regeneration.";
RL PLoS Biol. 15:E2003790-E2003790(2017).
CC -!- SIMILARITY: Belongs to the importin alpha family.
CC {ECO:0000256|ARBA:ARBA00010394, ECO:0000256|PIRNR:PIRNR005673}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIK33523.1}.
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DR EMBL; MRZV01002510; PIK33523.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G8JCR1; -.
DR STRING; 307972.A0A2G8JCR1; -.
DR Proteomes; UP000230750; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.20.5.690; Importin-alpha, importin-beta-binding domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032413; Arm_3.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR002652; Importin-a_IBB.
DR InterPro; IPR036975; Importin-a_IBB_sf.
DR InterPro; IPR024931; Importin_alpha.
DR PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR PANTHER; PTHR23316:SF71; IMPORTIN SUBUNIT ALPHA; 1.
DR Pfam; PF00514; Arm; 8.
DR Pfam; PF16186; Arm_3; 1.
DR Pfam; PF01749; IBB; 1.
DR PIRSF; PIRSF005673; Importin_alpha; 1.
DR SMART; SM00185; ARM; 8.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 2.
DR PROSITE; PS51214; IBB; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR005673};
KW Reference proteome {ECO:0000313|Proteomes:UP000230750};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005673}.
FT DOMAIN 1..63
FT /note="IBB"
FT /evidence="ECO:0000259|PROSITE:PS51214"
FT REPEAT 122..164
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 164..192
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
SQ SEQUENCE 530 AA; 59144 MW; 58BEF0F2EE5C22FE CRC64;
MCRYKFFTSI CQPKNIRDFS KNAALNPEEL RRRREETGIQ LRKQKREEQL FKRRNVDLPI
DSEHDMGMPD NFMSTQTQFV TQEMVDIINN GDQSQQLQAT QQFRKLLSKE PNPPINEVIQ
TAIVPKFVQF LSAENSTLQF EAAWVLTNIA SGTSAQTRTV IDTGAVPIFI KLLQSQYEDV
QEQAVWALGN IAGDSPECRD YVLKEGILLP LLSLLTNAVR MSMVRNAVWA LSNLCRGKSP
PPEFKEVSPC LPVLARLLFS GDPDVLADAC WALSYLSDGP NEKIQAVIDS GVCRRLVELL
VHPAQSVVSA ALRAVGNTVT GDDVQTQVIL HCNALPCLLS LLSHTKESIR KEACWTISNI
TAGNRSQIQA VIDANIIPML VEILSKAEFR TRKEAAWAIT NATSGGSAEQ IKFIVSEGCI
KPLCDLLTVM DAKIVHVALT GLENILKLGQ AEAQISREPN QYALDIESCS GLDKIEFLQS
HDNPEIYRKS FEIIEEYFSQ DDDESTQLVP NVEGQEFQFG VEENAENLQF
//
