ID   A0A2G8JFM9_STIJA        Unreviewed;       858 AA.
AC   A0A2G8JFM9;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   24-JAN-2024, entry version 11.
DE   SubName: Full=Endonuclease-reverse transcriptase {ECO:0000313|EMBL:PIK34564.1};
GN   ORFNames=BSL78_28610 {ECO:0000313|EMBL:PIK34564.1};
OS   Stichopus japonicus (Sea cucumber).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC   Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX   NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK34564.1, ECO:0000313|Proteomes:UP000230750};
RN   [1] {ECO:0000313|EMBL:PIK34564.1, ECO:0000313|Proteomes:UP000230750}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Shaxun {ECO:0000313|EMBL:PIK34564.1};
RC   TISSUE=Muscle {ECO:0000313|EMBL:PIK34564.1};
RX   PubMed=29023486;
RA   Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA   Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA   Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA   Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT   "The sea cucumber genome provides insights into morphological evolution and
RT   visceral regeneration.";
RL   PLoS Biol. 15:E2003790-E2003790(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PIK34564.1}.
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DR   EMBL; MRZV01002136; PIK34564.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2G8JFM9; -.
DR   STRING; 307972.A0A2G8JFM9; -.
DR   Proteomes; UP000230750; Unassembled WGS sequence.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR47027; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR47027:SF8; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Endonuclease {ECO:0000313|EMBL:PIK34564.1};
KW   Hydrolase {ECO:0000313|EMBL:PIK34564.1};
KW   Nuclease {ECO:0000313|EMBL:PIK34564.1};
KW   Nucleotidyltransferase {ECO:0000313|EMBL:PIK34564.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000230750};
KW   RNA-directed DNA polymerase {ECO:0000313|EMBL:PIK34564.1};
KW   Transferase {ECO:0000313|EMBL:PIK34564.1}.
FT   DOMAIN          406..660
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   858 AA;  100321 MW;  B649411029B6BA1D CRC64;
     MNKPSLPRPP VPSSSASLDQ GGGSVRTLLG EDRLIELEQE LEEVKWDVIG LSEVRRRGEQ
     LEQLKSGHHL FHIGKKDKSE AGVGFLVHKS LTGNVTEFKG VNERLAQLTI KINKRYSLKI
     IQVYAPTSSY DVMRSKHCQG RKCSQQSQHR QRPQNGNGKF QINTKLERQK LLRPKYSNIN
     LHKLTERNKF QLELANKFGT LNDEWREQDL DTWNQETIDI IQEAALNVAG RKPKDRVSKL
     SDSTRKLIGK RRQMKMDSQG TDNIEYRETC KTIRKKIRED VRNYNTKMIH DAIENNRSIK
     KTNKKLGQGT KKINKLLDSN GQEITDQDDI LRRIEKFYEE LYQSNQQTGD IDDSQEKVPK
     VECWEVEYAL SQMTRGKAPG QDNIMMDTLK EAGDAVNKEL AKLFTACLYQ GKVPQKWKDA
     NMIILHKKGD KRDLKNYRPI SLLSNIYKLF TKILTNRLER LLDDNQPREQ EGFRRNFSTI
     DHIHTLNQLK EKCQEFNIPV CVAFVDYEKA FDSVETWAVL EALKEQDINP NYIKVIKDIY
     TGSTTTVKLH KESNKIPIRK GVRQGDTISP KLFTACLEQI FKDINWEDKG INVNGEKLNH
     LRFADDIVII ANSFNEMESM LQDLDIASRK RGLKMNMKKT KVMADQSVKH KPIIINGTEL
     EHVSEYIYLG QRFTLTERNE DNEIRRRIKA GWQAFGRYSH IMKGNLPLCL KRKVYDQCIL
     PSMTYASETW TLTIKMERKL AAAQHNMERS MLNITCKDHK TNKWIREQTK VQDIMEVIKH
     RKWTWAGHVT RRGDGRWSTL TTVWTPLDGK RNIGRQSKRW RDEIQKFWNE TNWYTHARER
     ESWRYHAEAF IQQWIDNG
//