ID A0A2G8JH42_STIJA Unreviewed; 174 AA.
AC A0A2G8JH42;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE SubName: Full=Sodium/calcium exchanger 1 {ECO:0000313|EMBL:PIK35063.1};
GN ORFNames=BSL78_28114 {ECO:0000313|EMBL:PIK35063.1};
OS Stichopus japonicus (Sea cucumber).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK35063.1, ECO:0000313|Proteomes:UP000230750};
RN [1] {ECO:0000313|EMBL:PIK35063.1, ECO:0000313|Proteomes:UP000230750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Shaxun {ECO:0000313|EMBL:PIK35063.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PIK35063.1};
RX PubMed=29023486;
RA Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT "The sea cucumber genome provides insights into morphological evolution and
RT visceral regeneration.";
RL PLoS Biol. 15:E2003790-E2003790(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIK35063.1}.
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DR EMBL; MRZV01001997; PIK35063.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G8JH42; -.
DR STRING; 307972.A0A2G8JH42; -.
DR Proteomes; UP000230750; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005432; F:calcium:sodium antiporter activity; IEA:InterPro.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 1.
DR InterPro; IPR004836; Na_Ca_Ex.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR PANTHER; PTHR11878:SF65; NA_CA-EXCHANGE PROTEIN, ISOFORM G; 1.
DR PANTHER; PTHR11878; SODIUM/CALCIUM EXCHANGER; 1.
DR Pfam; PF01699; Na_Ca_ex; 1.
DR PRINTS; PR01259; NACAEXCHNGR.
PE 4: Predicted;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Ion transport {ECO:0000256|ARBA:ARBA00022568};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000230750};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022568}.
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..164
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
SQ SEQUENCE 174 AA; 18735 MW; 8D4FAF7A00D00CC4 CRC64;
MGLLHRLHHL DRDSNGTDRR PRTMFGCTIG LMDSVTAISF VALGTSVPDT FASKVAAVGD
KHADASIGNV TGSNAVNVFL GIGVAWTLAS FKHLMDGNQF CVDPGSLGFS VTLYTCFAVV
SISVLMIRRV HPKIGAELGG PKWAKIPTSL FFVCLWLLYI LISTLEAYDV IQGF
//
