ID A0A2G8JMG8_STIJA Unreviewed; 768 AA.
AC A0A2G8JMG8;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=Putative DNA mismatch repair protein Msh2 {ECO:0000313|EMBL:PIK36899.1};
GN ORFNames=BSL78_26269 {ECO:0000313|EMBL:PIK36899.1};
OS Stichopus japonicus (Sea cucumber).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK36899.1, ECO:0000313|Proteomes:UP000230750};
RN [1] {ECO:0000313|EMBL:PIK36899.1, ECO:0000313|Proteomes:UP000230750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Shaxun {ECO:0000313|EMBL:PIK36899.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PIK36899.1};
RX PubMed=29023486;
RA Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT "The sea cucumber genome provides insights into morphological evolution and
RT visceral regeneration.";
RL PLoS Biol. 15:E2003790-E2003790(2017).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIK36899.1}.
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DR EMBL; MRZV01001598; PIK36899.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G8JMG8; -.
DR STRING; 307972.A0A2G8JMG8; -.
DR Proteomes; UP000230750; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 1.
DR Gene3D; 6.10.140.80; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF35; DNA MISMATCH REPAIR PROTEIN MSH2; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 3.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000230750}.
FT DOMAIN 572..588
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT COILED 356..383
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 768 AA; 85951 MW; 45A4FB191AA8F882 CRC64;
MSHTQPCQTS SLEVVANINE YYTVHGSDAT FAAKEVFKTT GVIKYLGSGA NKVESVSLSK
MNFESLVKDL LLIRKYRVEV YQNRSAGRNE WVLAYKASPG NLTQFEEILF GHNDMSTSAS
VIAVKYVSDG GQRLVGVGFC DPTLRELGVC EFVDNDQFSN LELLGDESNF GQFKLKTFDL
SQYMKLDSAA VRALNLLPTG LEGVNKSMSV LGLLNKCKTA QGQRLLAQCG LKQTLNGKKN
LEERLNAVES FVDDTELRQL LQDEHLKRIP DFQRLSKKLQ RKKATLQDCY RVYQAIDFMP
EIIDALNRYD GNHSSLLKEL FVKPLQEHLM DFGKFQEMIE TTVDLQQALN QEYLIRADFD
ENLTALRSKM DTLERDIEAQ LGKAATSLGL EAGKTIKLES NNMLGYFFRV TRKDEKVLRN
STKFTTIDTN KNGVRFTNST LKSLNDEHLT SKEDYSETQK AVVTEVINIA AGYVEPMLSL
NEVTAQLDVL ISFAQVSSSA PVSYVRPKIL EKGTGVIKVV QGRHPCLEVQ DDVAFIPNDI
TFERDKQMFH IITGPNMGGK STFIRQNGTE NSLIIIDELG RGTSTYDGFG LAWGISDFIA
RKVRGYCLFA THFHELTALA DEIVTVNNLH VTALTSDGQL TLLYRVKPGV CDQSFGIQVA
ELAHFPLKVI NNAKVKAAEL EDYQSIAASD GCMEGLDEPA AKRKRMAKEK GESIIERFVS
KVKGLPWDSI SDEEAWEKMQ EFKTEVAAEQ NPFIEEILSR GQMLSTVQ
//
