ID   A0A2G8JP18_STIJA        Unreviewed;       769 AA.
AC   A0A2G8JP18;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Putative breast cancer type 2 susceptibility protein-like {ECO:0000313|EMBL:PIK37511.1};
DE   Flags: Fragment;
GN   ORFNames=BSL78_25644 {ECO:0000313|EMBL:PIK37511.1};
OS   Stichopus japonicus (Sea cucumber).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC   Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX   NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK37511.1, ECO:0000313|Proteomes:UP000230750};
RN   [1] {ECO:0000313|EMBL:PIK37511.1, ECO:0000313|Proteomes:UP000230750}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Shaxun {ECO:0000313|EMBL:PIK37511.1};
RC   TISSUE=Muscle {ECO:0000313|EMBL:PIK37511.1};
RX   PubMed=29023486;
RA   Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA   Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA   Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA   Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT   "The sea cucumber genome provides insights into morphological evolution and
RT   visceral regeneration.";
RL   PLoS Biol. 15:E2003790-E2003790(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PIK37511.1}.
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DR   EMBL; MRZV01001489; PIK37511.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2G8JP18; -.
DR   STRING; 307972.A0A2G8JP18; -.
DR   Proteomes; UP000230750; Unassembled WGS sequence.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR   InterPro; IPR015525; BRCA2.
DR   InterPro; IPR015252; BRCA2_hlx.
DR   InterPro; IPR036315; BRCA2_hlx_sf.
DR   InterPro; IPR002093; BRCA2_repeat.
DR   PANTHER; PTHR11289:SF0; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN; 1.
DR   PANTHER; PTHR11289; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2; 1.
DR   Pfam; PF09169; BRCA-2_helical; 1.
DR   Pfam; PF00634; BRCA2; 5.
DR   SUPFAM; SSF81872; BRCA2 helical domain; 1.
DR   PROSITE; PS50138; BRCA2_REPEAT; 6.
PE   4: Predicted;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   Reference proteome {ECO:0000313|Proteomes:UP000230750};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          654..769
FT                   /note="Breast cancer type 2 susceptibility protein helical"
FT                   /evidence="ECO:0000259|Pfam:PF09169"
FT   REGION          308..332
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          473..528
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        308..323
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        474..489
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        491..528
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         769
FT                   /evidence="ECO:0000313|EMBL:PIK37511.1"
SQ   SEQUENCE   769 AA;  83700 MW;  742420256003CA21 CRC64;
     MTKCLKLLPK GNWQTLDGNF TSGFQTASGT KVKISQTALK KAKELMSEDS LTVSENDKMF
     ETTAERKLAT LDGNFTSGFQ TASGTKVKIS QNALKKAKEL MSDDLLTVNG KDGKLPTIQG
     SKRVDPDSKF QTFDGRRSST DGNISAKTKM KGHVSSSGFQ TASGSEVKIS LSALEQAQKL
     MLSEENISKV GHKYIDGKLQ NCNKSRPEQS AIARARCVPT FQTASGSRVD VSESALLKAK
     KLLAEDLEPP VRCMTAGKSF EETHLANKTA NIMEGDGKFC GFQTASGSHV KVSEAALEKA
     KRLWDDEGSI KESDERTGNP SSSHERLERC PSGFATASGG KVTISSTSLE RAKDILTDGD
     KEMQMGQGSR KLSAGQHLCG TSRKEDCPDV GRIATGGFLT GKGKAVAISE LALKQARERW
     VDNAGMEEHS ASSLENVKGH TEQVNGLYQN SASGVPSLEV SENGRCNIRN VMKEDGSLTE
     HERGEAERMS TMQGKVSTHH CDVTAVTSSP EDQRTPRRAT PQTGQAFTSQ FKQKIKNAQN
     SPLPTDNKEK SNSSAISPQL SINHQPMRIH PASCLTDRIL TSGPLKPLNS KFRIDEQTVI
     SICFSSFHLL LLYEHHLAVT TPKEAKIFER KQHIKEHLKE EAENEDVDMK LIWQIARLAQ
     TKRIQSKKKL LIKPVKGALS KLKADKDRIT LREAVNHELP RNHSEGEIFS AGVLPSTLLI
     SAESASSYRF EGAEFYGREP LASSDGILSG DGGRLILGDD GAAGVKEFT
//