ID A0A2G8JSL3_STIJA Unreviewed; 1099 AA.
AC A0A2G8JSL3;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Putative talin-1 isoform X2 {ECO:0000313|EMBL:PIK38708.1};
DE Flags: Fragment;
GN ORFNames=BSL78_24457 {ECO:0000313|EMBL:PIK38708.1};
OS Stichopus japonicus (Sea cucumber).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK38708.1, ECO:0000313|Proteomes:UP000230750};
RN [1] {ECO:0000313|EMBL:PIK38708.1, ECO:0000313|Proteomes:UP000230750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Shaxun {ECO:0000313|EMBL:PIK38708.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PIK38708.1};
RX PubMed=29023486;
RA Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT "The sea cucumber genome provides insights into morphological evolution and
RT visceral regeneration.";
RL PLoS Biol. 15:E2003790-E2003790(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIK38708.1}.
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DR EMBL; MRZV01001323; PIK38708.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G8JSL3; -.
DR STRING; 307972.A0A2G8JSL3; -.
DR Proteomes; UP000230750; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0005925; C:focal adhesion; IEA:InterPro.
DR GO; GO:0001726; C:ruffle; IEA:InterPro.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd10569; FERM_C_Talin; 1.
DR CDD; cd17090; FERM_F1_TLN; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 3.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.20.1420.10; Talin, central domain; 2.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR032425; FERM_f0.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR035964; I/LWEQ_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015224; Talin_cent.
DR InterPro; IPR036476; Talin_cent_sf.
DR InterPro; IPR049108; Talin_R4.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR19981:SF1; RHEA, ISOFORM B; 1.
DR PANTHER; PTHR19981; TALIN; 1.
DR Pfam; PF16511; FERM_f0; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF09141; Talin_middle; 1.
DR Pfam; PF21692; Talin_R4; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM01244; IRS; 1.
DR SUPFAM; SSF109880; A middle domain of Talin 1; 1.
DR SUPFAM; SSF109885; I/LWEQ domain; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000230750}.
FT DOMAIN 42..370
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 442..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 988..1041
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 444..461
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:PIK38708.1"
FT NON_TER 1099
FT /evidence="ECO:0000313|EMBL:PIK38708.1"
SQ SEQUENCE 1099 AA; 119779 MW; 0CB10386C7A9BFFD CRC64;
AEYGLFLHDE DPKKGVWLES GKTLEHYMLR EADILEYRKK IRPLRVKMLD GSVKTVLIDD
SHTASQMLVT ICTKLGVTNY DEYSLCRDED DPSDPKARKD ATLNRGTLKK DKDKTSILRD
EKKMDTLKRK LHTDDELNWL DHTRTLREQG VEDTETLIFR RKYFYSDQNV DKRDPVQLNL
LYVQSRDAIL NGTHPCSQEE ATQLAGTQCQ ILYNDHQEAK HKAGFLDLKV MLPKEYVKIK
GIEKKIFVEH KKLLGVNELD AKVRYTQLCR SLKTYGITFF LVKEKMKGKN KLVPRLLGIN
KESVVRVDER TKEILKTWPL THVRRWAASP KSFTLDFGDY SEAYYSVQTT EGEQIGQLIG
GYIDIILKKK KGKDRTGIEG EEEATLLEDS VSPAKATFIQ HQSNSKGQYE MGSVAMPGIM
RQGGQAGHIS RGEMGDPLHA MSTGQGHTAH QPPMNSARQP GLTSAQMNLK SSIDYSFTTM
EDSMRNLDEK HQLNIGDDEA SLQWRKNEID LNRQMVESQM SAMAAATAGI ITQSNDPNER
DYTVIGSHVT TISSNMTEMT KGIKMLAALL EEEDGSQNLI DATKDMMMAF KDLLNAASPE
TEENRQELLS AANKVAEAQS ALFQAMSSTG YMEPGFQDTL MQLAKAVANA TATLVLNSKN
VASTAEEEEM RNQVIGEATN CALNTSQLVA VTRVVAPTIS NPACQEQLVE AAKLVAKSVE
RVVDSSKQAT EDENLLMNVG EAATAVTKAL NDLLQHVKQG TAGHKPGTVY DDACDRIVVA
TDKLFSSVGN ATEMVKQAKV LAQASSLLVG AIKGDAEGLG EGDSQQKLLG AARELADATA
RMIEAAKGCA GSPNDAAQQH RLRQAAEDLR SATNLAANNA LKKKLITRLE NAAKQAAALS
TQTISAAQGA DLHNTNKSSQ QELIDECRVT AEHIPALVHG VRDSMNQPDS TKAQVNLINA
SQNFLAPGNN LVTASKAAVP TVSDPSSAMQ LNNVSKNLAN ALAELKAAAA KAQEACGSLE
LDNAVEMIRT LNGELDQMHQ TAEDGKLVPL PGQVPANCAA QLGSTSKGVG ASMASLLTSA
AQGNENHTGI AARDTANSL
//
