ID   A0A2G8JSR5_STIJA        Unreviewed;      1218 AA.
AC   A0A2G8JSR5;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Putative 77 kDa echinoderm microtubule-associated protein {ECO:0000313|EMBL:PIK38759.1};
GN   ORFNames=BSL78_24409 {ECO:0000313|EMBL:PIK38759.1};
OS   Stichopus japonicus (Sea cucumber).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC   Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX   NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK38759.1, ECO:0000313|Proteomes:UP000230750};
RN   [1] {ECO:0000313|EMBL:PIK38759.1, ECO:0000313|Proteomes:UP000230750}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Shaxun {ECO:0000313|EMBL:PIK38759.1};
RC   TISSUE=Muscle {ECO:0000313|EMBL:PIK38759.1};
RX   PubMed=29023486;
RA   Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA   Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA   Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA   Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT   "The sea cucumber genome provides insights into morphological evolution and
RT   visceral regeneration.";
RL   PLoS Biol. 15:E2003790-E2003790(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PIK38759.1}.
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DR   EMBL; MRZV01001318; PIK38759.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2G8JSR5; -.
DR   STRING; 307972.A0A2G8JSR5; -.
DR   Proteomes; UP000230750; Unassembled WGS sequence.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   Gene3D; 3.10.20.230; Doublecortin domain; 2.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR003533; Doublecortin_dom.
DR   InterPro; IPR036572; Doublecortin_dom_sf.
DR   InterPro; IPR005108; HELP.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR13720:SF55; ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE CG42247; 1.
DR   PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR   Pfam; PF03607; DCX; 2.
DR   Pfam; PF03451; HELP; 1.
DR   Pfam; PF00400; WD40; 4.
DR   SMART; SM00537; DCX; 2.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF89837; Doublecortin (DC); 2.
DR   SUPFAM; SSF50978; WD40 repeat-like; 2.
DR   PROSITE; PS50309; DC; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000230750};
KW   WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT   DOMAIN          144..225
FT                   /note="Doublecortin"
FT                   /evidence="ECO:0000259|PROSITE:PS50309"
FT   DOMAIN          299..385
FT                   /note="Doublecortin"
FT                   /evidence="ECO:0000259|PROSITE:PS50309"
FT   REPEAT          898..930
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          1052..1093
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REGION          23..118
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          250..269
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          468..502
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        23..50
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1218 AA;  137048 MW;  B21E810F814004F3 CRC64;
     MTANRPAVNS LYVYETPRSL RYSKNSIRGN PTPNELQLPD GATSITSRRK YRLSPVAPGY
     GPYGSRYTDP SDDERTDYDL DGDITSGNPR GWKTEKAPKR RQQNDFSPSQ SRTHDDDMFR
     YLPPRKRFEP ETRPDNRQSK FATKVVTFYR NGDKHFQGVQ LPVNGKIFRT WESLLTVLNG
     KIPLPYGVRN IYTLTGDEVK NVVELVDGRA YVCASGQFNP RIPYGKVEFA DKHWSNRRLS
     AGANRHSDRR LLTLKDGDGG EERKSRALAS NIDADPSSIN KSTSILAIDP SVSHFVKPRV
     VTVISNTHRG SRAKILINPK TTQTFEQIMK DVTQSIVMSN PPVKQLFTWR TEEKVLSFTQ
     LFRDFRDHDK FIACGLEPIK RTTHLQQRSV DEEVVPNQKL PHSTIRDEEN ERLVRIEQAG
     YYVQRFQDWK RRAKNQEDPV GTFVPNGYPF TVKKQGGGYA QNFRQHKEYH ETSPPLLPPL
     KPRRAFGGSS SEESSPRDYD NDFRGGGAVA AAWRAKLSAP GAILAGVDRK GVHVINAAKP
     RRSKDVASAI EQIEEIIEDD LPQKIKEREK QRKGVEKNVD ANKQKRKVLA PPAVAEVLGE
     RKEFLAPTDA EIGSKNVYKP PKKKLKLEWV YGYHGFKDSN NLFTLSSGEY LYTVGAIAVL
     HDPELDQQRH YTGHNEDIQA LAVHPAGNYV ATGQVAGNMS QAVPPDVATC HSWKTDIPTG
     CSFMTSVTYS HVRVWEVETL HTHAIIGLDF FEGGISCLAF SKENNGEWLM AVDRGIPHTV
     SVWDWNEDYV MVKSREYSLF DNPSQEESNT AVTVGAFHPY EDTILVTAGR KHIHFWRFNH
     NKLFRDKRSG VFDEERPEFV TSLEFSPTGD VLTGDSSGNI SVWEKDHDSA FRLRYRIQRA
     HEKSVFALRM LEDGTLLSGG GIDRRLLAWD SLHGYVSAKV ERLFPEYAGG IRTIALVNPG
     SADGQMLIEP CSCSVFHPSG NMIAIGTTVG RLIVLSSNDG MHIASVQVSR DQINVVRFSP
     DGSYLAVGCQ DCRIYIYTVM DEGQVYRKQG ILQGHPENVT HIDWSNDGQY LQSVSAAYDL
     LFWSVDEMAQ EGAASLRDVT WKTQTCILGY TVAGIWPTND RFAKIQSVDR SRQSKLAISG
     DQNGQLSLYT YPCSSYKFQP NESKAQSSHI GTAKFIHDDS YVISAGGSDA VLMQWAIVDK
     NNLQSNHHII DEEDEYGT
//