ID   A0A2G8JT52_STIJA        Unreviewed;       624 AA.
AC   A0A2G8JT52;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   SubName: Full=Putative guanylate cyclase soluble subunit beta-2 isoform X2 {ECO:0000313|EMBL:PIK38941.1};
GN   ORFNames=BSL78_24236 {ECO:0000313|EMBL:PIK38941.1};
OS   Stichopus japonicus (Sea cucumber).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC   Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX   NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK38941.1, ECO:0000313|Proteomes:UP000230750};
RN   [1] {ECO:0000313|EMBL:PIK38941.1, ECO:0000313|Proteomes:UP000230750}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Shaxun {ECO:0000313|EMBL:PIK38941.1};
RC   TISSUE=Muscle {ECO:0000313|EMBL:PIK38941.1};
RX   PubMed=29023486;
RA   Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA   Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA   Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA   Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT   "The sea cucumber genome provides insights into morphological evolution and
RT   visceral regeneration.";
RL   PLoS Biol. 15:E2003790-E2003790(2017).
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC       family. {ECO:0000256|RuleBase:RU000405}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PIK38941.1}.
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DR   EMBL; MRZV01001299; PIK38941.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2G8JT52; -.
DR   STRING; 307972.A0A2G8JT52; -.
DR   Proteomes; UP000230750; Unassembled WGS sequence.
DR   GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 6.10.250.780; -; 1.
DR   Gene3D; 3.30.450.260; Haem NO binding associated domain; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR018297; A/G_cyclase_CS.
DR   InterPro; IPR011645; HNOB_dom_associated.
DR   InterPro; IPR042463; HNOB_dom_associated_sf.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR45655; GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2; 1.
DR   PANTHER; PTHR45655:SF13; SOLUBLE GUANYLATE CYCLASE GCY-35-RELATED; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF07701; HNOBA; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW   Reference proteome {ECO:0000313|Proteomes:UP000230750}.
FT   DOMAIN          311..439
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REGION          28..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          548..624
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          252..283
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        36..57
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        553..583
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        590..606
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   624 AA;  70737 MW;  2DE8396AB3952506 CRC64;
     MEVLDESHEE ERNGKKEHVT FAIFVQKKKH PKPPPTIVTT DQTNDLNQSQ MNGSTKPVMD
     DDPTDDVIDT ENRGNDIEKD IVPGSQSIMN LVTNFTPFYP ERLWLSQEVF CEYFPYHIVF
     DSYLRPLQTG LHIQRLLPTL QSTEADTLDS FFKIIHPQID WKLSSMRKFI NMQFVLETKR
     SVITQGWGKD RPMLQLRGQM IWMENLNAML YVCSPRVASL KELEDRCLHL SDIPQHDVTR
     DLILFNHQRL AEIELGKQLE QKKEELRNAL NDLEAEKQKT DMLLHSMLPR QVADQLREGK
     KVEAGEFTIV TILFSDIVSF TNICAECRPI DIVNMLNALY VRFDKLTSVH DVYKVETIGD
     AYMVVGGLPI PVPSHADRIA NMALGMTVAC QEVMSPVTRE PIKIRVGIHS GPVVAGVVGR
     KMPRYCLFGD TVNTASRMES HGLPGKIHIS SASCQCLIEE NFEISERGEI LVKGKGTMKT
     YFVNENKNAS MEEIMGKKRK ASTPEKKDSV KLETDSLIKF GTDPYSHNTE AIPMVYNDED
     RMAEFMKTPQ RKLTPAPSDS NSDTTKPEDQ SSNDVTTDNA HRATTSSESK RNEIVEATQN
     HGATNFGRRS RRADIQGSRT CAIL
//