ID A0A2G8JWA6_STIJA Unreviewed; 307 AA.
AC A0A2G8JWA6;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Putative hairy/enhancer-of-split related with YRPW motif protein 1 {ECO:0000313|EMBL:PIK40047.1};
GN ORFNames=BSL78_23105 {ECO:0000313|EMBL:PIK40047.1};
OS Stichopus japonicus (Sea cucumber).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK40047.1, ECO:0000313|Proteomes:UP000230750};
RN [1] {ECO:0000313|EMBL:PIK40047.1, ECO:0000313|Proteomes:UP000230750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Shaxun {ECO:0000313|EMBL:PIK40047.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PIK40047.1};
RX PubMed=29023486;
RA Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT "The sea cucumber genome provides insights into morphological evolution and
RT visceral regeneration.";
RL PLoS Biol. 15:E2003790-E2003790(2017).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIK40047.1}.
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DR EMBL; MRZV01001170; PIK40047.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G8JWA6; -.
DR STRING; 307972.A0A2G8JWA6; -.
DR Proteomes; UP000230750; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd11407; bHLH-O_HERP; 1.
DR Gene3D; 6.10.250.980; -; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003650; Orange_dom.
DR PANTHER; PTHR10985; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED; 1.
DR PANTHER; PTHR10985:SF138; HAIRY_ENHANCER-OF-SPLIT RELATED WITH YRPW MOTIF PROTEIN; 1.
DR Pfam; PF07527; Hairy_orange; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00511; ORANGE; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF158457; Orange domain-like; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000230750}.
FT DOMAIN 24..79
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 107..137
FT /note="Orange"
FT /evidence="ECO:0000259|PROSITE:PS51054"
FT REGION 151..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 307 AA; 33663 MW; C12A8055777D115D CRC64;
MAADKQGPTI DILGPYRSPF IHLWGREAME IIEKRRRDRI NNSLTELRRL VPAAFEKQGS
AKLEKAEILQ MTVDHLKYLH AKGIDGSFHP YGEAHAYAMD YRVLGLRECA SEVARYLVTV
EGMDLQDPLR LRLLSHLQCY MAQREIQSRQ HWNSVSSGHP GQFPAHTHGQ TPGLPHNSVT
SSDPHAAVLP PPPTGPGPES VGTRQMLPIM PTTSNHENQH QGSCHSRIPA PQPGSITTTA
AGSCNTSTNL STPVAPSIPA IHPQYPVTYN SLQVLSPNGY SATSGAHNAH TTIVSKPYRP
WGAEMAY
//
