ID A0A2G8JZA6_STIJA Unreviewed; 509 AA.
AC A0A2G8JZA6;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=GDNF/GAS1 domain-containing protein {ECO:0000259|SMART:SM00907};
GN ORFNames=BSL78_22080 {ECO:0000313|EMBL:PIK41072.1};
OS Stichopus japonicus (Sea cucumber).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK41072.1, ECO:0000313|Proteomes:UP000230750};
RN [1] {ECO:0000313|EMBL:PIK41072.1, ECO:0000313|Proteomes:UP000230750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Shaxun {ECO:0000313|EMBL:PIK41072.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PIK41072.1};
RX PubMed=29023486;
RA Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT "The sea cucumber genome provides insights into morphological evolution and
RT visceral regeneration.";
RL PLoS Biol. 15:E2003790-E2003790(2017).
CC -!- SIMILARITY: Belongs to the GDNFR family.
CC {ECO:0000256|ARBA:ARBA00005961}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIK41072.1}.
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DR EMBL; MRZV01001056; PIK41072.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G8JZA6; -.
DR STRING; 307972.A0A2G8JZA6; -.
DR Proteomes; UP000230750; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR InterPro; IPR016017; GDNF/GAS1.
DR InterPro; IPR037193; GDNF_alpha.
DR InterPro; IPR003438; GDNF_rcpt.
DR PANTHER; PTHR10269; GDNF RECEPTOR ALPHA; 1.
DR PANTHER; PTHR10269:SF12; GLIAL CELL LINE-DERIVED NEUROTROPHIC FAMILY RECEPTOR-LIKE, ISOFORM E; 1.
DR Pfam; PF02351; GDNF; 2.
DR SMART; SM00907; GDNF; 2.
DR SUPFAM; SSF110035; GDNF receptor-like; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000230750};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 35..113
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
FT DOMAIN 137..217
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
SQ SEQUENCE 509 AA; 56329 MW; B0769115B644CCCE CRC64;
MTEQRCNMTW MFFNGSCKGQ ATNSITVPQV QSHTCVDAEQ TCLRDSKCAT TLRTYTENCV
GLSESVCSTL RGNCGVLKSE VDETILKDCI CPVENDTDIT CEQIWETFHK DPCVSSCETI
LHEETLIGGE HDGGSTCQTA VDQCYNNSTC YSYFSSYLSA CLIDMTTGRC NHDQCMRAMR
DVFTTVPPSL THALVFCYCK EDDSLCHGLK SALSPQCVEG DNPTVSCLTI KTRCEAKPAA
GDYALCRNAF VGTFGTLLST TCICEEAEPV KQDICLQYLR LITQNPCVEK ASKSYFTDLT
EQTKSGCFIP TSSDDERNHG IMMPTGVYAK FSSQNSTRQT ACLCSETGRL VDCFSFPANH
ISSCDQRNES QSVTSVTHTP TSQYGYEKSL CTCVNGERVC INERIESVFN TPALDLPFLL
VAYSEKEVAL VNNESRRMIT TSAILGRLED VLKDILKAPN CYCTDYKEYR HVLEFSFTAA
KLKRGFILHA KLPGEGQPPA CQCCRPAIK
//
