ID A0A2G8K118_STIJA Unreviewed; 681 AA.
AC A0A2G8K118;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=Leucine-rich repeat-containing protein 74A {ECO:0008006|Google:ProtNLM};
GN ORFNames=BSL78_21462 {ECO:0000313|EMBL:PIK41680.1};
OS Stichopus japonicus (Sea cucumber).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK41680.1, ECO:0000313|Proteomes:UP000230750};
RN [1] {ECO:0000313|EMBL:PIK41680.1, ECO:0000313|Proteomes:UP000230750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Shaxun {ECO:0000313|EMBL:PIK41680.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PIK41680.1};
RX PubMed=29023486;
RA Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT "The sea cucumber genome provides insights into morphological evolution and
RT visceral regeneration.";
RL PLoS Biol. 15:E2003790-E2003790(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIK41680.1}.
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DR EMBL; MRZV01000997; PIK41680.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G8K118; -.
DR STRING; 307972.A0A2G8K118; -.
DR Proteomes; UP000230750; Unassembled WGS sequence.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR24114; LEUCINE RICH REPEAT FAMILY PROTEIN; 1.
DR PANTHER; PTHR24114:SF2; PH DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13516; LRR_6; 7.
DR SMART; SM00368; LRR_RI; 8.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS51450; LRR; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000230750};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..681
FT /note="Leucine-rich repeat-containing protein 74A"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013863022"
FT REGION 66..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 196..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 229..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..84
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 681 AA; 75639 MW; 29940E34FE8811EB CRC64;
MLHSHWCILL TLYKLLDNVG TLFNPRGSRC TEYRAIVYNV LDFILSHCNA FKQIPNPKLL
ESRKRISKKK KCSEDRDQRE DSSSNDLEGI SGSSPSKSPR FDNTPHTAFL QSILQAKDHD
IIAVSDAKNS MEEFQTSTHT LHDTPSTNDA IKDGGHLTPL HENSASLPVE ATSNVHPSYS
VCDDGVEEIP WSVTELKSGT EDKEEDVDDG LEQSQTRRSF LALSIKYEEK SDEKTDLDEG
SEDPSRKFRE ERQKQLREAA KSLMEGADVY NDEDYDTDLE EDFPKEPEPR LDEAGVSVYI
QECKMEGVDP SPYVKNHLKG TTFVMRHRYL GMRAFLPFAR AMQKNTTVEF LNLSDNRIDS
LGSSAVAEMM RDNCYVTRLD MSHNLMGSPG TAAFASMLEI NYTLKRLCLK ANHLTDKDAQ
LLAEGLKNNV TLTDLDLSSN DFGEAAGIHL GKGLASNDGL VYLDLGWNAI RAKGVLEIAS
ALKVNSSLEV LDLSRNGINL PGCQAMLRAL KLNQGLKILD LSHNHITSEG ARKISLGLKK
NSSLEGLLLS GNRIGDVGIL ALLKAIGTGK TGIRLLGLQD IPMPVAVHNK CTEIQAKFDV
CILQLDVDGR RKFMPPSHVT AMVDQFIAEN AARFLSSLLH LDEQKKRALS SDDIINILSQ
LGIDMNQVTF LSVCLRQKME I
//
