ID   A0A2G8K142_STIJA        Unreviewed;      1058 AA.
AC   A0A2G8K142;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   22-FEB-2023, entry version 14.
DE   SubName: Full=Putative presequence protease, mitochondrial {ECO:0000313|EMBL:PIK41727.1};
GN   ORFNames=BSL78_21427 {ECO:0000313|EMBL:PIK41727.1};
OS   Stichopus japonicus (Sea cucumber).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC   Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX   NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK41727.1, ECO:0000313|Proteomes:UP000230750};
RN   [1] {ECO:0000313|EMBL:PIK41727.1, ECO:0000313|Proteomes:UP000230750}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Shaxun {ECO:0000313|EMBL:PIK41727.1};
RC   TISSUE=Muscle {ECO:0000313|EMBL:PIK41727.1};
RX   PubMed=29023486;
RA   Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA   Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA   Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA   Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT   "The sea cucumber genome provides insights into morphological evolution and
RT   visceral regeneration.";
RL   PLoS Biol. 15:E2003790-E2003790(2017).
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|RuleBase:RU004447}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PIK41727.1}.
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DR   EMBL; MRZV01000993; PIK41727.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2G8K142; -.
DR   STRING; 307972.A0A2G8K142; -.
DR   Proteomes; UP000230750; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR001431; Pept_M16_Zn_BS.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   InterPro; IPR013578; Peptidase_M16C_assoc.
DR   PANTHER; PTHR43016; PRESEQUENCE PROTEASE; 1.
DR   PANTHER; PTHR43016:SF13; PRESEQUENCE PROTEASE, MITOCHONDRIAL; 1.
DR   Pfam; PF08367; M16C_assoc; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 2.
DR   SMART; SM01264; M16C_associated; 1.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR   PROSITE; PS00143; INSULINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:PIK41727.1};
KW   Protease {ECO:0000313|EMBL:PIK41727.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000230750}.
FT   DOMAIN          487..734
FT                   /note="Peptidase M16C associated"
FT                   /evidence="ECO:0000259|SMART:SM01264"
SQ   SEQUENCE   1058 AA;  118455 MW;  0ECBDD91C2BEA519 CRC64;
     MEGRFRSGVV QIVYEGIQHY QKRLCKTTSL ELCSMDIRLR RSPELYLTAI KLSHLQTGAE
     HLHIARDDTN NVFSVGFRTT PMDNSGVSHI LEHTVLCGSQ RFPCRDPFFK MLNRSLSTFM
     NAFTASDYTM YPFSTQNSKD FQNLLSVYLD AVFFPNLNHL DFLQEGWRLE HDSNEDKGSP
     ITFKGVVFNE MKGAMSSPDQ LYAVHCQNML LPSHTYSYNS GGNPNDILNL THEQLREFHA
     THYHPSNARF YTYGDLPLES HLEQINSLAL DRFHKIEPGT SIPNETRWTE KLLSIVHCCV
     MSPDPDKQTT VSVSYLLPRI TEVHESFEMS FLASLLTSGP TSPFYQSLLD TNIGAGYSPV
     CGYDGSTREA SFSVGLQGIL AEDEQKVKEI IRSTLEKVTE EGFEAERIEA VLHSVELAQK
     HQTTSFGLGL VMSLMSVWNQ DGDPISSMQL DKLVSSFKQK IADNPRYLQD LVQKYLVNNQ
     HQLWLRMTAD ENYNTNQEKA EMDKLNTLVQ ALDENTKEQI YQAGIELAES QNQEVDVSCL
     PTVTVGDINP NTRRTDIKTE CLDGSYVQLH EQPTNGVTYF KAVSPLGLAD QELVQYLPLF
     CNVVTQMGTK NMSFRELAKE EELRTGGLGV GPHIIQRRED TTSYEVGVAL SSHCLERNLH
     EMFGLWQDIF QSVTLSDQER LTTLVRMEAA EMANSVSFMG HAYAMRGAAS SLSPVGQIGE
     VTGGMSQVNL MKQIAELDDL SDVVSKLTQL SSVLLNRSNM RFCLNAAPSG MSPAVEALDS
     FLTKLPGRRG SRSSLEDAIS VTKDGDFSAV SSCRHFQLPF PVNYVSMGTT AVPYKHEDFA
     KLVVLARLLS AKFLHKEIRE KGGAYGSGAT MSNDGTFKFY SYRDPRSMET LDVFHQSLPW
     IQSQNFTNQD LDEAKIALFS NVDAPIAPGS RGVSTFLNGV TDDDRQIQRD RLFAVTREDV
     VDVAQRKTKL PTHNSVVVKW LRQWTCDLRI TGSSPGQIIA LCPWARHFIS IASLHPGVKW
     DLPVTCKYSC MRRFVAAPYG KSQGHVAVVH CGAPGEIV
//