ID A0A2G8K1S1_STIJA Unreviewed; 742 AA.
AC A0A2G8K1S1;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:PIK41957.1};
GN ORFNames=BSL78_21192 {ECO:0000313|EMBL:PIK41957.1};
OS Stichopus japonicus (Sea cucumber).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK41957.1, ECO:0000313|Proteomes:UP000230750};
RN [1] {ECO:0000313|EMBL:PIK41957.1, ECO:0000313|Proteomes:UP000230750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Shaxun {ECO:0000313|EMBL:PIK41957.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PIK41957.1};
RX PubMed=29023486;
RA Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT "The sea cucumber genome provides insights into morphological evolution and
RT visceral regeneration.";
RL PLoS Biol. 15:E2003790-E2003790(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIK41957.1}.
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DR EMBL; MRZV01000973; PIK41957.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G8K1S1; -.
DR STRING; 307972.A0A2G8K1S1; -.
DR Proteomes; UP000230750; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR PANTHER; PTHR24418:SF294; NON-SPECIFIC PROTEIN-TYROSINE KINASE; 1.
DR PANTHER; PTHR24418; TYROSINE-PROTEIN KINASE; 1.
DR Pfam; PF08205; C2-set_2; 2.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PIRSF; PIRSF000615; TyrPK_CSF1-R; 2.
DR SMART; SM00409; IG; 3.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Magnesium {ECO:0000256|PIRSR:PIRSR000615-3};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000615-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000230750};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 461..484
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 134..175
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 240..336
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 345..428
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 452..742
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 648
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR000615-3"
SQ SEQUENCE 742 AA; 83262 MW; EF78EC978D4F54E2 CRC64;
MVWSGLFSSH GSTIEKIMII FRTAIYLPFC IAILYFSSFA STTTPPQNIY ATIGSVLNLN
CTVTSKLNRA WDFNDEPLYL GKIPTEEWIG ISISLLEDYS LRFHELSSIH EGVYVCRQGL
YILATYEVII QVRPRLKMSI NGKPAINSTV FIADGKEANV SCFAEGARPE VNLVWRGLSE
ANWEIIYVSY NTSLGIKDTF DASSDLVIVP RSATATLACL SSQEGDFPGE LFTIYFKIIP
TMVISINNKG SDVTVPMATT LTVLCSAYGA RPPSKLTWFF NGREIDDIAN TDILPNKKRN
GTFDCFSILT YQPEDTNGTI TCHSTLNNTK VEKSVHAAFL TFVLPTITLS INGETSSVVN
VDNKEAMRVE CLVREARPAM VITWFLDDKP ISPSAIHTNS STKRSNGNYD SESSLRLIPS
SKVGIISCVC KGLPIGMLTT NITFHSVEQD EIMQRRYIGK LLILVVLASV VLLGFFFICI
FICGKGTTLT YDGRIQFQLR WKKTILSRLN KFRKTKMRCK KTCPDDNHYV EDIMKKSGFH
WDEYVKRLLD LPNANHITNI EGICIEEATL YVVHEHLTCE VLENVIGYGQ QERESKFLDH
LILDTKTSSY ATDVLEGMEF IQSYGFLHPG LSTKKVLVTG QKICKLYDFC LREDAPTKVK
IIKNKVESNL EFLAPEAVQR SEYDQTSDVW ATAVVIWRIL YKGKFTIEIN HSDTYEVPAG
CITDNYVPMK GQLSDSNGSI SP
//
