ID A0A2G8K361_STIJA Unreviewed; 473 AA.
AC A0A2G8K361;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Putative ileal sodium/bile acid cotransporter-like {ECO:0000313|EMBL:PIK42389.1};
GN ORFNames=BSL78_20751 {ECO:0000313|EMBL:PIK42389.1};
OS Stichopus japonicus (Sea cucumber).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK42389.1, ECO:0000313|Proteomes:UP000230750};
RN [1] {ECO:0000313|EMBL:PIK42389.1, ECO:0000313|Proteomes:UP000230750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Shaxun {ECO:0000313|EMBL:PIK42389.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PIK42389.1};
RX PubMed=29023486;
RA Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT "The sea cucumber genome provides insights into morphological evolution and
RT visceral regeneration.";
RL PLoS Biol. 15:E2003790-E2003790(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the bile acid:sodium symporter (BASS) (TC
CC 2.A.28) family. {ECO:0000256|ARBA:ARBA00006528}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIK42389.1}.
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DR EMBL; MRZV01000938; PIK42389.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G8K361; -.
DR STRING; 307972.A0A2G8K361; -.
DR Proteomes; UP000230750; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR002657; BilAc:Na_symport/Acr3.
DR InterPro; IPR004710; Bilac:Na_transpt.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR PANTHER; PTHR10361:SF65; ILEAL SODIUM_BILE ACID COTRANSPORTER; 1.
DR PANTHER; PTHR10361; SODIUM-BILE ACID COTRANSPORTER; 1.
DR Pfam; PF01758; SBF; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000230750};
KW Signal {ECO:0000256|SAM:SignalP}; Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022847}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..473
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013788899"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 174..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 205..228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 240..263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 275..294
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 306..324
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 336..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 400..420
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 436..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..460
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 473 AA; 52470 MW; C6ADC89A757A49D1 CRC64;
MMFSAKSAIF VAVVLFACLT SGQVPEEDQE LITLVRLLED DTGEEELAEV LLSVEDEVTV
DFMIVNEELG DYLVRSSDER VFEVEVLGND DNTVPVNETF QVKISGKFLG IESLQFVDVE
GDLIAATYTI KVKRVPKAIS VIFTYTLLVW LIISYVSMGA LMDWPTLKER LYPPWPIIIG
MICQFILMPL VTFILANILP VDNPTAVGIV LVGTCPGGWL SNIFSVLLDV DFILSVTMTF
FSSIAGMAMM PFNIFIYATP FIQDNTNLQT PFGDLALNLV LLVVACVIGI LLGWKFEKFR
TFCEKVLKPI AVLLVVFGLG LGIPADIHMF YSDWPIWVAA LVTPLIGAYL GLSLARIFAL
PIKKSVTIAL ETGVQNALLA RTVVYLYYPQ PEGDLVGRVQ TLTVLITLVE GCLISIIYQL
SRFLFCRGKN DDEVDLKEDE SKVRETNGNK LPDKSHEAES GIENPAFYDK TVV
//
