ID A0A2G8K519_STIJA Unreviewed; 568 AA.
AC A0A2G8K519;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE SubName: Full=Putative lanosterol synthase {ECO:0000313|EMBL:PIK43101.1};
GN ORFNames=BSL78_20051 {ECO:0000313|EMBL:PIK43101.1};
OS Stichopus japonicus (Sea cucumber).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK43101.1, ECO:0000313|Proteomes:UP000230750};
RN [1] {ECO:0000313|EMBL:PIK43101.1, ECO:0000313|Proteomes:UP000230750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Shaxun {ECO:0000313|EMBL:PIK43101.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PIK43101.1};
RX PubMed=29023486;
RA Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT "The sea cucumber genome provides insights into morphological evolution and
RT visceral regeneration.";
RL PLoS Biol. 15:E2003790-E2003790(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIK43101.1}.
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DR EMBL; MRZV01000876; PIK43101.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G8K519; -.
DR STRING; 307972.A0A2G8K519; -.
DR Proteomes; UP000230750; Unassembled WGS sequence.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd02892; SQCY_1; 1.
DR Gene3D; 1.50.10.20; -; 2.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000230750};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 21..202
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 262..564
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
SQ SEQUENCE 568 AA; 65414 MW; DFEC17B8A2323B0C CRC64;
MTFFIEGGFF LGGYLYFNRH IEGDATVFGT ALNYISMRLL GVSPEDGDMK RARKVLHHHG
GASAIPSWGK FWLCILNCYK WEGMHTMFPE LWLMPSWIPA HPSTLWIHCR MVYIGMAFLY
GKRYYAQEDE LIMDLRKELF IEDFDQIDWP SQRDNIAKID LYTPHSWLFN IAFGILDKYE
PFRLTRFRKQ ALDVCLDHIK QDDLMTSFIS IGPISKMINM LIRWLEDGPE SEAFKKHVER
VYDYVWMGLD GTNVQGTNGN QVWDTSFAAM AMLDVGAQDD PQFHEVLCKT YSYLEISQVI
ESSPDCVKYY RQYNKGGWAQ TMREHGLVVS DTSAEALKAV LLMNDKCPFI TERVSKRRLR
DAVDMLLTMV NPNGGFSSYE NLRGGTILEL LNPSEVFGDI MVDYTYTECT SSVLQALRHF
VDSDPDYRQD EIWAVLRNAM EYIRSNQLPD GSFEGSWGVC FTYGTWFALE AFACMGKNYQ
DNTASIDVKK ACSFLVSRQM EDGGWGEKFA SCSERRYVQS EKSLVVNTSW ALLGLMAVRY
PDQAVLERGI QVLRDRQHED GDWPQVTS
//