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Database: UniProt
Entry: A0A2G8K5W1_STIJA
LinkDB: A0A2G8K5W1_STIJA
Original site: A0A2G8K5W1_STIJA 
ID   A0A2G8K5W1_STIJA        Unreviewed;       263 AA.
AC   A0A2G8K5W1;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=NTR domain-containing protein {ECO:0000259|PROSITE:PS50189};
GN   ORFNames=BSL78_19750 {ECO:0000313|EMBL:PIK43391.1};
OS   Stichopus japonicus (Sea cucumber).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC   Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX   NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK43391.1, ECO:0000313|Proteomes:UP000230750};
RN   [1] {ECO:0000313|EMBL:PIK43391.1, ECO:0000313|Proteomes:UP000230750}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Shaxun {ECO:0000313|EMBL:PIK43391.1};
RC   TISSUE=Muscle {ECO:0000313|EMBL:PIK43391.1};
RX   PubMed=29023486;
RA   Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA   Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA   Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA   Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT   "The sea cucumber genome provides insights into morphological evolution and
RT   visceral regeneration.";
RL   PLoS Biol. 15:E2003790-E2003790(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PIK43391.1}.
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DR   EMBL; MRZV01000853; PIK43391.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2G8K5W1; -.
DR   Proteomes; UP000230750; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 2.40.50.120; -; 1.
DR   InterPro; IPR001134; Netrin_domain.
DR   InterPro; IPR001820; TIMP.
DR   InterPro; IPR008993; TIMP-like_OB-fold.
DR   PANTHER; PTHR11844; METALLOPROTEASE INHIBITOR; 1.
DR   PANTHER; PTHR11844:SF25; NTR DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00965; TIMP; 1.
DR   SMART; SM00206; NTR; 1.
DR   SUPFAM; SSF50242; TIMP-like; 1.
DR   PROSITE; PS50189; NTR; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW   ECO:0000256|PIRSR:PIRSR601820-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR601820-1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000230750};
KW   Zinc {ECO:0000256|PIRSR:PIRSR601820-1}.
FT   DOMAIN          35..185
FT                   /note="NTR"
FT                   /evidence="ECO:0000259|PROSITE:PS50189"
FT   BINDING         38
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="ligand shared with metalloproteinase partner"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601820-1"
FT   DISULFID        40..160
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT   DISULFID        50..185
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT   DISULFID        188..239
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT   DISULFID        205..230
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
SQ   SEQUENCE   263 AA;  30888 MW;  6EB0A7BD123BBABA CRC64;
     MTLLYIEHAT EEGIRCYVNG EVQRRRPKCV HAITCGACMC RPQHPQEAYC DADFVIRGRV
     TDVEKVEAPL PTIPEYNDPA GRNYEYSDYF SSRLFSKIIY TVEVKKRYKG DRNYFAPWAL
     VPITSRYVSD DCIHVPLYTN STFIIMGNQS TDGELLIDRC SFHRFFDQVT SNEIDGFRRH
     YKKTCNQCTV CHNTTGCEYD EADGCTVGKD IHKDVYYSNV TQCEHKFARC SRKKRTGRCH
     WIGNEIFRYC KRQRKKEVRR WPN
//
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