ID A0A2G8K7G0_STIJA Unreviewed; 849 AA.
AC A0A2G8K7G0;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 08-NOV-2023, entry version 15.
DE RecName: Full=G-protein coupled receptors family 2 profile 2 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=BSL78_19209 {ECO:0000313|EMBL:PIK43944.1};
OS Stichopus japonicus (Sea cucumber).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK43944.1, ECO:0000313|Proteomes:UP000230750};
RN [1] {ECO:0000313|EMBL:PIK43944.1, ECO:0000313|Proteomes:UP000230750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Shaxun {ECO:0000313|EMBL:PIK43944.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PIK43944.1};
RX PubMed=29023486;
RA Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT "The sea cucumber genome provides insights into morphological evolution and
RT visceral regeneration.";
RL PLoS Biol. 15:E2003790-E2003790(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIK43944.1}.
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DR EMBL; MRZV01000813; PIK43944.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G8K7G0; -.
DR Proteomes; UP000230750; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15039; 7tmB3_Methuselah-like; 1.
DR Gene3D; 4.10.410.20; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR036024; Somatomedin_B-like_dom_sf.
DR InterPro; IPR001212; Somatomedin_B_dom.
DR PANTHER; PTHR45902; LATROPHILIN RECEPTOR-LIKE PROTEIN A; 1.
DR PANTHER; PTHR45902:SF1; LATROPHILIN RECEPTOR-LIKE PROTEIN A; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01033; Somatomedin_B; 1.
DR SMART; SM00201; SO; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF90188; Somatomedin B domain; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS00524; SMB_1; 1.
DR PROSITE; PS50958; SMB_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000230750};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 551..571
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 583..601
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 613..637
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 658..681
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 704..732
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 752..775
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 781..805
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 51..91
FT /note="SMB"
FT /evidence="ECO:0000259|PROSITE:PS50958"
FT DOMAIN 549..807
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 849 AA; 96460 MW; F0400D82F893E17C CRC64;
MVDLQNRLRP LEVVSRTHSI SDITSMIFLF FSRLCFVEAS ILGQDVFLCG SHHTCHGRCG
SWRHGCSCDD LCTYFKDCCF DYEDLCYNKP TDVPSTFPSK VDKNRYECHD FLNVNIFVVS
KCSPYWTDDF LKSSCQQDQP STDITSHIPV YDNDGVVYRN IFCALCSDVK LTELTAFQAL
LVSYNWTADR NVTSAKRPFR GISFPTSILG TPRTCFKTQY ICSGDNMDLC QAYYAPVALA
ERNPTCLECE SGVVDYCSRE DCQLHEVTCN GVRKAPLFDL FDYSLQEKNS HDQCDISLGQ
LFDPFLQSCR FMGCPEEYFY SVGQCVEGSL PYGAPQVVLN TTISASLECI RSALSMNEME
ISELYLTAIP NNKTSSGPFS VTVVAESLLA SFFIKITLDS MLLSPAGRYE VYYKCATATF
LLTVKQTDRN ATEDPCYDSI VTFDNTPDEL SDTVSLFQNV FSYEYNPIIN EFDRHDLSDV
CWKSLNVELE CLDKSLIHPG EFQLAPSRTQ IVVSVLHGEI TLETSEFEMM RNGSMRVCTE
KLNSRSHLYE IFYNVCTAIS LVSLMFTLIT YQTFPKLRNV PGLCLMNLVA ALFLANFTFL
LNKEFVHMPS VCISVAAFSH FTWLASFAWM SVLSYNMART FGTHSMQLHT TGNAKSRLLK
FCIYAWGLPF VIMASCVFLH YCDCIDEFVF QYGGTSTCWI KDGFAVFITV GIPVATMLLF
DLAVFLYTGI SLRKSRHFTK HTRTNSALAN DLFVELAVNA RLFILLGITW IFGFIQEFWP
IPVWQITFLI SNSLQGLFIF VMFVMKKRVL NMWLNLFKNH RVDETTPTTK KADDQLKQSQ
IIPAIMPQL
//
