ID A0A2G8K905_STIJA Unreviewed; 198 AA.
AC A0A2G8K905;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=DNA-directed RNA polymerase III subunit RPC9 {ECO:0000256|ARBA:ARBA00016672};
GN ORFNames=BSL78_18656 {ECO:0000313|EMBL:PIK44484.1};
OS Stichopus japonicus (Sea cucumber).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK44484.1, ECO:0000313|Proteomes:UP000230750};
RN [1] {ECO:0000313|EMBL:PIK44484.1, ECO:0000313|Proteomes:UP000230750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Shaxun {ECO:0000313|EMBL:PIK44484.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PIK44484.1};
RX PubMed=29023486;
RA Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT "The sea cucumber genome provides insights into morphological evolution and
RT visceral regeneration.";
RL PLoS Biol. 15:E2003790-E2003790(2017).
CC -!- FUNCTION: Accessory protein for the calcitonin gene-related peptide
CC (CGRP) receptor. It modulates CGRP responsiveness in a variety of
CC tissues. {ECO:0000256|ARBA:ARBA00043924}.
CC -!- SUBUNIT: Component of the RNA polymerase III complex consisting of 17
CC subunits: a ten-subunit horseshoe-shaped catalytic core composed of
CC POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10,
CC POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and
CC POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and
CC CRCP/RPC9, protruding from the core and functioning primarily in
CC transcription initiation; and additional subunits homologous to general
CC transcription factors of the RNA polymerase II machinery, POLR3C/RPC3-
CC POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription
CC initiation and POLR3D/RPC4-POLR3E/RPC5 heterodimer involved in both
CC transcription initiation and termination.
CC {ECO:0000256|ARBA:ARBA00044007}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the eukaryotic RPC9 RNA polymerase subunit
CC family. {ECO:0000256|ARBA:ARBA00006898}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIK44484.1}.
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DR EMBL; MRZV01000774; PIK44484.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G8K905; -.
DR STRING; 307972.A0A2G8K905; -.
DR Proteomes; UP000230750; Unassembled WGS sequence.
DR GO; GO:0005666; C:RNA polymerase III complex; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006384; P:transcription initiation at RNA polymerase III promoter; IEA:InterPro.
DR Gene3D; 1.20.1250.40; -; 1.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR006590; RNA_pol_Rpb4/RPC9_core.
DR InterPro; IPR005574; Rpb4/RPC9.
DR InterPro; IPR038324; Rpb4/RPC9_sf.
DR InterPro; IPR038846; RPC9.
DR PANTHER; PTHR15561; CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN; 1.
DR PANTHER; PTHR15561:SF0; DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9; 1.
DR Pfam; PF03874; RNA_pol_Rpb4; 1.
DR SMART; SM00657; RPOL4c; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW ECO:0000313|EMBL:PIK44484.1}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000230750};
KW Transcription {ECO:0000256|ARBA:ARBA00023163}.
FT DOMAIN 46..157
FT /note="RNA polymerase Rpb4/RPC9 core"
FT /evidence="ECO:0000259|SMART:SM00657"
FT REGION 143..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..173
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..198
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 198 AA; 22509 MW; FE8C47A746F37FA9 CRC64;
MSRQRPHSDR EVLQCIHFSA RPVFFAKQKN KAECYTYSHA LIRSPSINEN AAMLSNYEVL
TLLKELQSQN GASKGKSGKI QQNLATISYE TVTYLEKTPC KYQSPEIIQK LLQELAPFSL
TKAEKLQLLN HCPTTAVEIQ LGEEKKGKKK GRKKRQEEGE EEEGCKGREG DKEGEEDGED
EQEDEEMEAE EAIEVIED
//
