ID A0A2G8K9J6_STIJA Unreviewed; 442 AA.
AC A0A2G8K9J6;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Putative signal-induced proliferation-associated 1-like protein 2 isoform X3 {ECO:0000313|EMBL:PIK44678.1};
GN ORFNames=BSL78_18472 {ECO:0000313|EMBL:PIK44678.1};
OS Stichopus japonicus (Sea cucumber).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK44678.1, ECO:0000313|Proteomes:UP000230750};
RN [1] {ECO:0000313|EMBL:PIK44678.1, ECO:0000313|Proteomes:UP000230750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Shaxun {ECO:0000313|EMBL:PIK44678.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PIK44678.1};
RX PubMed=29023486;
RA Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT "The sea cucumber genome provides insights into morphological evolution and
RT visceral regeneration.";
RL PLoS Biol. 15:E2003790-E2003790(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIK44678.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MRZV01000762; PIK44678.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G8K9J6; -.
DR STRING; 307972.A0A2G8K9J6; -.
DR Proteomes; UP000230750; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15711:SF70; RAP-GAP DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000230750}.
FT DOMAIN 1..124
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT DOMAIN 275..339
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 378..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..396
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 442 AA; 49618 MW; 35F68CCF4CF96603 CRC64;
MLKVWMKLPR KRHVGNDIVT IIFQEPGSLP FTPKSVRSHF QHIFIVIRAH EPNTDDVHYS
VAVSRSKDVP VFGPPLPPDA IFAKSSAFAD FIIAKAINAE NAVHKTEKFV AMATRTRKEY
LKDLAMNHVT NSTIDPGGKF SLFNKKKEKS CPRPAPDFRA KGALVWDIMV YLWAPITKGS
HLHLQMEDYS LADPVSCFLG ISPDMIVLLK TESRETLFSI PCKAVIGWTP QPHSLKLYFN
EGNCIRMRIN DHDLDEIPEI VKRLEAVTTG TKTQEITLRR NGLGQLGFHV HFQGIVVEVD
PYGYTWQAGL RKGARLVEIC EIAVCTQTHE EMIDLLRTSM TVKVSVVPPY GDGSPRRGTT
PMEYISSDED MHNMRPAFTR SRSTGRGPTK VYNTFHATSR EPAPAGTGKS SPSSYPYPPK
PLNRRIANPG NVRVAIQTFE RK
//
