ID   A0A2G8KBF7_STIJA        Unreviewed;       576 AA.
AC   A0A2G8KBF7;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   24-JAN-2024, entry version 10.
DE   RecName: Full=Reverse transcriptase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=BSL78_17802 {ECO:0000313|EMBL:PIK45337.1};
OS   Stichopus japonicus (Sea cucumber).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC   Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX   NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK45337.1, ECO:0000313|Proteomes:UP000230750};
RN   [1] {ECO:0000313|EMBL:PIK45337.1, ECO:0000313|Proteomes:UP000230750}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Shaxun {ECO:0000313|EMBL:PIK45337.1};
RC   TISSUE=Muscle {ECO:0000313|EMBL:PIK45337.1};
RX   PubMed=29023486;
RA   Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA   Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA   Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA   Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT   "The sea cucumber genome provides insights into morphological evolution and
RT   visceral regeneration.";
RL   PLoS Biol. 15:E2003790-E2003790(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PIK45337.1}.
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DR   EMBL; MRZV01000718; PIK45337.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2G8KBF7; -.
DR   STRING; 307972.A0A2G8KBF7; -.
DR   Proteomes; UP000230750; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   CDD; cd09076; L1-EN; 1.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR19446:SF435; LINE-1 RETROTRANSPOSABLE ELEMENT ORF2 PROTEIN; 1.
DR   PANTHER; PTHR19446; REVERSE TRANSCRIPTASES; 1.
DR   Pfam; PF03372; Exo_endo_phos; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000230750}.
FT   DOMAIN          4..199
FT                   /note="Endonuclease/exonuclease/phosphatase"
FT                   /evidence="ECO:0000259|Pfam:PF03372"
FT   DOMAIN          470..573
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|Pfam:PF00078"
SQ   SEQUENCE   576 AA;  64548 MW;  37D9186B61098ED6 CRC64;
     MEVDCVCLQE THILEEDVPL WAYEWGGELH ASFGSSSSCG TVILLSARQA GCATRVETDH
     EGRLVCILFK YPQGNIAICN VYAPNRPSAR RDFFNTLPSF VPGSAPCVMV GDFNCVPDSG
     LDRLGTSVSA SPDAGITELD RFTSAHLLAD VWRHMHPCST VYTWVRPNGE DASRIDRVYA
     PVSFTFSGCE TLSCPLSDHD TVVARFVLPS IFPIGRGLWK LNCRILGEAE FRQGFETRYK
     GWQTLKPAFA STSQWWDEVK LRIKRYAIQY CVTRARRRRE KFSKLCAEVK FGDPSAVIAL
     QTYLDEKYHG ARVRARVEAV EAEERPSLRF YQSVSSSAGD RRVPSVRATD GTVVSDPHGI
     VRVYKEYYSS LFTRGNVDLS AQADLLRGIS KTVPHDVNDI LGGEITTVEL WKALSKMKNG
     KSPGSDGLPR EFYRTFWAII GPDIRAVFED AFQNGLLNQS QRLGMITLLP KSGDPLDPRN
     KRPITLLNVD YKLLAKALCN RLALAMPHLV GDLQTCAVKG HCIQQNLWLM RDLTDFVIER
     DLPCALVSLD QQKAFDMVDR GFLMNVLETF QLHPFS
//