ID A0A2G8KDD6_STIJA Unreviewed; 554 AA.
AC A0A2G8KDD6;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=DNA polymerase alpha subunit B {ECO:0000256|ARBA:ARBA00018596};
GN ORFNames=BSL78_17107 {ECO:0000313|EMBL:PIK46017.1};
OS Stichopus japonicus (Sea cucumber).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK46017.1, ECO:0000313|Proteomes:UP000230750};
RN [1] {ECO:0000313|EMBL:PIK46017.1, ECO:0000313|Proteomes:UP000230750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Shaxun {ECO:0000313|EMBL:PIK46017.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PIK46017.1};
RX PubMed=29023486;
RA Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT "The sea cucumber genome provides insights into morphological evolution and
RT visceral regeneration.";
RL PLoS Biol. 15:E2003790-E2003790(2017).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA polymerase alpha subunit B family.
CC {ECO:0000256|ARBA:ARBA00007299}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIK46017.1}.
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DR EMBL; MRZV01000670; PIK46017.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G8KDD6; -.
DR STRING; 307972.A0A2G8KDD6; -.
DR Proteomes; UP000230750; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.60.21.60; -; 2.
DR Gene3D; 1.10.8.530; DNA polymerase alpha-primase, subunit B, N-terminal domain; 1.
DR InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR InterPro; IPR043034; DNA_pol_alpha_B_N_sf.
DR InterPro; IPR016722; DNA_pol_alpha_bsu.
DR InterPro; IPR013627; Pol_alpha_B_N.
DR PANTHER; PTHR23061; DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT; 1.
DR PANTHER; PTHR23061:SF12; DNA POLYMERASE ALPHA SUBUNIT B; 1.
DR Pfam; PF04042; DNA_pol_E_B; 1.
DR Pfam; PF08418; Pol_alpha_B_N; 1.
DR PIRSF; PIRSF018300; DNA_pol_alph_2; 2.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000230750}.
FT DOMAIN 24..163
FT /note="DNA polymerase alpha subunit B N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08418"
FT DOMAIN 301..506
FT /note="DNA polymerase alpha/delta/epsilon subunit B"
FT /evidence="ECO:0000259|Pfam:PF04042"
FT REGION 124..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 554 AA; 61038 MW; 9CA696DD602795CA CRC64;
MSSIVDANEL SSAFGIFSVE LNDSVIDKLI ELCTVYRLDA NDISEEWIAM SYQHNQADLT
LTMLDKLENE VLQKKPVKLK KPPSRQSTPV LFESPTLFDT PEEDDGLLNA YTPVGKANLQ
RRTFKTPESS QKRKHTQGGI SPIMSTPSQK YGIRGNKGEV VAKFGNLSVH SGLDLRLLND
MIEEMSQHLQ EKYNIEELSH VAIPLQEKVS VVGRICCDSV GKLNPQSVLL EGSVETSAGK
RVPLKLTEVN NYSLFPGQII ALEGINSTGS HMVASKIYEG VSPSSPKDID SSLSNHGSLH
VVMAAGPFTT SDSLSYEPLE DLCQIINTKS PDVCIMFGPF VDCNQEQISS GNIDKTFPEL
FLCCMQEILK NTEGSGTQLV VLPSLRDVHH DFVYPQPPFD DLPRGKTERL HFVSEPSTFT
ANGIVFGATS TDVLLHLGKE EISGTATTGD RLGRLMKHIF TQQSFYPVHP PPEDVPIDYA
HYEEYARLTV KPHIFIAPSD MRYFIKDIDG TLCINPGRLS KGQGGGTFAE LVIQPGQKAD
TSITNRAAAR IVRI
//
