ID   A0A2G8KFZ8_STIJA        Unreviewed;       507 AA.
AC   A0A2G8KFZ8;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   13-SEP-2023, entry version 12.
DE   RecName: Full=SH2 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=BSL78_16216 {ECO:0000313|EMBL:PIK46916.1};
OS   Stichopus japonicus (Sea cucumber).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC   Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX   NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK46916.1, ECO:0000313|Proteomes:UP000230750};
RN   [1] {ECO:0000313|EMBL:PIK46916.1, ECO:0000313|Proteomes:UP000230750}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Shaxun {ECO:0000313|EMBL:PIK46916.1};
RC   TISSUE=Muscle {ECO:0000313|EMBL:PIK46916.1};
RX   PubMed=29023486;
RA   Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA   Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA   Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA   Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT   "The sea cucumber genome provides insights into morphological evolution and
RT   visceral regeneration.";
RL   PLoS Biol. 15:E2003790-E2003790(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PIK46916.1}.
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DR   EMBL; MRZV01000613; PIK46916.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2G8KFZ8; -.
DR   Proteomes; UP000230750; Unassembled WGS sequence.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd01670; Death; 1.
DR   CDD; cd00173; SH2; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF00017; SH2; 1.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000230750};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT   DOMAIN          169..230
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          411..458
FT                   /note="Death"
FT                   /evidence="ECO:0000259|PROSITE:PS50017"
FT   REGION          136..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   507 AA;  57308 MW;  FD6A2CF1ABC28F6F CRC64;
     MASGGVRDNV VYGALMFFSD SKKNRSKKKS NFVSKPVKFY QTAQLHETFD VQQEDHILHM
     QTSDKLTIFL RCNNVFIVHR HRDGAVAVLK NARFQQSNPP VTLDGSKYSV FMEGVGMTLM
     YAVALENCKE GSGIKSNVLR DAPPLPPPRL PPTETSQVQE ENTSRGEHWF KGRISRGKAE
     ELLKDEGDYL FRFKGHDSNT IVLSHCIGNE EFRHVIVLEE KESSCEEIRY EGTTAIHQRI
     LDFAKSAGLP FQDDEPIRLG GASVKAVNPY ATYSDIIARN DDKLFKPRQG ARKGDTEDTY
     EELYEPYLPC PMIGQKDHPE QRQVDPEPRS FTATPLLTTS SSVDYGGYEV VVAPENCKCT
     EESKEIDSLY NYIKETFDAS TLEVLRFLRE LGHKCVSDDI HSDVADHLVE AKWDEFGKLL
     KVPANIRHRI QKSSEDICER TVSLLKAWHQ RLGNGATLGF RGLGRIQLDE AGYGPAGKIF
     LGREKLLLLP YKRDPNNKND KANNAYL
//