ID A0A2G8KK47_STIJA Unreviewed; 1042 AA.
AC A0A2G8KK47;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN ORFNames=BSL78_14774 {ECO:0000313|EMBL:PIK48373.1};
OS Stichopus japonicus (Sea cucumber).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK48373.1, ECO:0000313|Proteomes:UP000230750};
RN [1] {ECO:0000313|EMBL:PIK48373.1, ECO:0000313|Proteomes:UP000230750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Shaxun {ECO:0000313|EMBL:PIK48373.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PIK48373.1};
RX PubMed=29023486;
RA Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT "The sea cucumber genome provides insights into morphological evolution and
RT visceral regeneration.";
RL PLoS Biol. 15:E2003790-E2003790(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIK48373.1}.
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DR EMBL; MRZV01000526; PIK48373.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G8KK47; -.
DR STRING; 307972.A0A2G8KK47; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000230750; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.60.90; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR010606; Mib_Herc2.
DR InterPro; IPR037252; Mib_Herc2_sf.
DR InterPro; IPR040847; SH3_15.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR PANTHER; PTHR24202; E3 UBIQUITIN-PROTEIN LIGASE MIB2; 1.
DR PANTHER; PTHR24202:SF4; E3 UBIQUITIN-PROTEIN LIGASE MIB2-RELATED; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF13857; Ank_5; 1.
DR Pfam; PF06701; MIB_HERC2; 2.
DR Pfam; PF18346; SH3_15; 2.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR Pfam; PF00569; ZZ; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 8.
DR SMART; SM00184; RING; 3.
DR SMART; SM00291; ZnF_ZZ; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF159034; Mib/herc2 domain-like; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 4.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS51416; MIB_HERC2; 2.
DR PROSITE; PS50089; ZF_RING_2; 2.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000230750};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00228}.
FT DOMAIN 1..75
FT /note="MIB/HERC2"
FT /evidence="ECO:0000259|PROSITE:PS51416"
FT DOMAIN 81..133
FT /note="ZZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50135"
FT DOMAIN 144..222
FT /note="MIB/HERC2"
FT /evidence="ECO:0000259|PROSITE:PS51416"
FT REPEAT 481..513
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 514..546
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 648..681
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 682..714
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 861..895
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 912..947
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 1042 AA; 114114 MW; 9352734C2158488A CRC64;
MESTVVGYRV VRGPDWRWND QDGGEGNLGT VVEVGKKGSS TSPEKTVIVQ WDNGSRTNYR
MGYHNAYDLL IYDNATVGIQ HVNILCDACN KQGFMGMRYN CTQCQDFDLC ASCYHGDKHD
LSHHFLLYIT PSSVGVKLPP RSSAIKIGYR GLVPGAKVMR GPDWDWGNQD GGDGKIGRIK
DIRGWDSESD RSVANVQWSN GNTNVYRVGH KGKVDLRCLD SVKGGTYYKD HLWKLGQKVA
KNSVSAYGKK WSFVHGEKVK VNLDVAVLKI MQGDHGGWNA KMEEYVGQEG YVHRITEKGD
IRVQYSDGIK WTFHPGALTK VTTFSVDDNV RITSDIEKLR KLQLGHGEWH EDMKMALGKV
GRVIKIYKDG DLRVCVNGQS WTYHCECVTA VESSQDVNVT VAAEASSSQQ QQQDPSGNVQ
RLKDRIRVLR KGEDCLDKLV TAAARGDVSV VGDLVLKRPG WVSYFTSRWI KQSLGLSTDR
VQKTALQVAA HQGHVDVVKI LVQAGANLSI PDQEGDTALH YAVFGNQPGI VRYLLEHGAE
VNLVNKGQCS SLHVAVNKSY MQCVEELIKK ECNVNLQDCC GDTALHDAIA KDNTEAIDIL
TNIADAEFTL ANRRGFNVLQ HAALKGNKRA TEKLVRAARQ LVNRKKDDGF SALHLASLNG
HRDVVEVLLT TGQADINIRN NRLQTPIHLA VSQGHVPVVE LLVSRGADLL ASDEDGDTCL
HVALMKPVVS PGGENLPVIR GIQATLGVSI RPGVALACFL IQEGADPSYL NTQSKSALDL
VKRNEAYPLS SSLWIIEGRN LFFEEIRFYL ALIGTIQPGR RIAVPNDTSS HVIEDANITD
ESDAIQQPQL VMSTSVSTTT CKLCHKMADC CLKPCKHITC CMECSQLFAL CPVCKGTIES
REKIETTDQS KCSLCKTNVA DVTLLPCRHR AACADCFQKM SVCAVCSEPI VEVITAGSAK
AVAGVSANSL SKSLSKDKEK ISKITTSNDK GRQMECAICM ERESSVVFLC GHTTCGTCAK
PLKYFGVVGG GRGWGVKAVV AD
//