ID   A0A2G8KKL2_STIJA        Unreviewed;       555 AA.
AC   A0A2G8KKL2;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   03-MAY-2023, entry version 12.
DE   RecName: Full=Death domain-containing protein {ECO:0000259|PROSITE:PS50017};
GN   ORFNames=BSL78_14598 {ECO:0000313|EMBL:PIK48543.1};
OS   Stichopus japonicus (Sea cucumber).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC   Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX   NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK48543.1, ECO:0000313|Proteomes:UP000230750};
RN   [1] {ECO:0000313|EMBL:PIK48543.1, ECO:0000313|Proteomes:UP000230750}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Shaxun {ECO:0000313|EMBL:PIK48543.1};
RC   TISSUE=Muscle {ECO:0000313|EMBL:PIK48543.1};
RX   PubMed=29023486;
RA   Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA   Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA   Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA   Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT   "The sea cucumber genome provides insights into morphological evolution and
RT   visceral regeneration.";
RL   PLoS Biol. 15:E2003790-E2003790(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PIK48543.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; MRZV01000517; PIK48543.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2G8KKL2; -.
DR   Proteomes; UP000230750; Unassembled WGS sequence.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd01670; Death; 2.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 3.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   Pfam; PF00531; Death; 3.
DR   SMART; SM00005; DEATH; 2.
DR   SUPFAM; SSF47986; DEATH domain; 3.
DR   PROSITE; PS50017; DEATH_DOMAIN; 3.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000230750}.
FT   DOMAIN          81..164
FT                   /note="Death"
FT                   /evidence="ECO:0000259|PROSITE:PS50017"
FT   DOMAIN          180..250
FT                   /note="Death"
FT                   /evidence="ECO:0000259|PROSITE:PS50017"
FT   DOMAIN          310..380
FT                   /note="Death"
FT                   /evidence="ECO:0000259|PROSITE:PS50017"
FT   REGION          450..471
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          486..555
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   555 AA;  63905 MW;  148E2291962C8A9E CRC64;
     MWKQLCHGLI SELELTNKWR TSAKKEHKDF FRLESVLQSW WKDIHEGHQA HLRRFLMFLG
     QYGREDIRDH IEKVPDRGCF DETVLNTVIL SATNSWKRFA AELGVEQREL TGKLTHDMNP
     YDCLRTVFNI WYTKEKGCNK LGQLLKACRA IGRETLADDI EQGLSEPVLR RIGHQIETKQ
     WRLLGEKLLI SEVRLDAFRE SFQLLPERVY RMLSYWSMLQ SFDANKTEML ASALCDINLG
     HVAEKELYKV PDRGCFDETV LNPVIHSATN SWKLFAAELG VEKHELAGKL TQGLNESVLR
     RMSHQIEHKQ WKLLGVKLLI PDVRLDAFRE TFQPLPERVY RMFSYWSMLQ SFDANKIEML
     ASVLCDINLG HVAEKELYKV AAHRHLASRP GQVRSITEPT VPLEGIGGET GDEEEVRELV
     GVEMERGQER AGEEREREME ICHPRCRRCP DVPPRARKGK AQGQPKAHVR ERERCRFCHP
     RCRRCPDVPP RARARARLKA NQKPMTKTAR ADSPSGSQRA APVVVRAKRG APESQGPARP
     QKEPGTDVPL RPKEG
//