ID   A0A2G8KL17_STIJA        Unreviewed;       602 AA.
AC   A0A2G8KL17;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=TIR domain-containing protein {ECO:0000259|Pfam:PF13676};
GN   ORFNames=BSL78_14479 {ECO:0000313|EMBL:PIK48667.1};
OS   Stichopus japonicus (Sea cucumber).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC   Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX   NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK48667.1, ECO:0000313|Proteomes:UP000230750};
RN   [1] {ECO:0000313|EMBL:PIK48667.1, ECO:0000313|Proteomes:UP000230750}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Shaxun {ECO:0000313|EMBL:PIK48667.1};
RC   TISSUE=Muscle {ECO:0000313|EMBL:PIK48667.1};
RX   PubMed=29023486;
RA   Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA   Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA   Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA   Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT   "The sea cucumber genome provides insights into morphological evolution and
RT   visceral regeneration.";
RL   PLoS Biol. 15:E2003790-E2003790(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PIK48667.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; MRZV01000509; PIK48667.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2G8KL17; -.
DR   STRING; 307972.A0A2G8KL17; -.
DR   Proteomes; UP000230750; Unassembled WGS sequence.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR46270:SF5; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE; 1.
DR   PANTHER; PTHR46270; ARMADILLO-TYPE FOLD-RELATED; 1.
DR   Pfam; PF13676; TIR_2; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000230750}.
FT   DOMAIN          367..476
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|Pfam:PF13676"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..29
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   602 AA;  68193 MW;  06D28930A1204977 CRC64;
     MGSSSSVQKK KLKEGDEGSK ADKTKKDKQK TLEDHLEALR AAIDYLSICS NFKTKDCYSY
     FVTIRSASNP PGMPIEERVH IADLVIELDY TSLFPLIWSD LHSVDLSQGH GKNKQPEESV
     PHQAMSNLKA FKAAWWNFTD WSTPLVVELG TTTALRSLVS DLEDPDLAVD KMSSESRRFL
     IKGSLGTIHN MVRRDAKLRM HIRKIENCVN LFTAYSRSTF LIIQAKSFLI LSYILCENEY
     AAMEATDNSI GFLVGMLRES LNYKNHKAKK YGFSSAEILQ GLNQIALNDP NKVKVMDNGA
     VPLMVRMLGD NCSIEEQTLA SEGLWKLAFA EDNKQRMREN TALMEAEDLK KPGQKRHTKV
     LPNKSHVMIS YQWDVQQSML SLRDALKNDG YNVWMDIDKL DGDILGGMAD AVEQAAVVLV
     CFSQRYKDSQ SCRTEATYAY KQNKTIVPLM VEPNYNPDGW LGALIGTLKY YKFYDESVKP
     SEYVELLHTL GNMGKQGYIL PQKEVLTGSS KPVSISREPT LTLQTDSRQI SGWSNSDVEE
     WLIKNDLSEA ASKFKDIDGE MLYQMYKQLQ RAPEFFHNAV SKELGLKYFQ VLKFTRALEK
     AV
//