ID A0A2G8KLK1_STIJA Unreviewed; 2026 AA.
AC A0A2G8KLK1;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=Putative laminin subunit gamma-1 isoform X1 {ECO:0000313|EMBL:PIK48845.1};
GN ORFNames=BSL78_14281 {ECO:0000313|EMBL:PIK48845.1};
OS Stichopus japonicus (Sea cucumber).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK48845.1, ECO:0000313|Proteomes:UP000230750};
RN [1] {ECO:0000313|EMBL:PIK48845.1, ECO:0000313|Proteomes:UP000230750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Shaxun {ECO:0000313|EMBL:PIK48845.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PIK48845.1};
RX PubMed=29023486;
RA Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT "The sea cucumber genome provides insights into morphological evolution and
RT visceral regeneration.";
RL PLoS Biol. 15:E2003790-E2003790(2017).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIK48845.1}.
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DR EMBL; MRZV01000498; PIK48845.1; -; Genomic_DNA.
DR STRING; 307972.A0A2G8KLK1; -.
DR Proteomes; UP000230750; Unassembled WGS sequence.
DR CDD; cd00055; EGF_Lam; 12.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 11.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000034; Laminin_IV.
DR InterPro; IPR013015; Laminin_IV_B.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574:SF435; LAMININ SUBUNIT GAMMA-1; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00052; Laminin_B; 1.
DR Pfam; PF00053; Laminin_EGF; 15.
DR Pfam; PF00055; Laminin_N; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00180; EGF_Lam; 14.
DR SMART; SM00281; LamB; 1.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 8.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01248; EGF_LAM_1; 7.
DR PROSITE; PS50027; EGF_LAM_2; 7.
DR PROSITE; PS51115; LAMININ_IVA; 1.
DR PROSITE; PS51116; LAMININ_IVB; 1.
DR PROSITE; PS51117; LAMININ_NTER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000230750};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..2026
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013836087"
FT DOMAIN 28..264
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 374..425
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 527..727
FT /note="Laminin IV type B"
FT /evidence="ECO:0000259|PROSITE:PS51116"
FT DOMAIN 733..782
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 783..831
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 832..878
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 939..1143
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 1178..1228
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1331..1377
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1378..1426
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT COILED 1972..2022
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 396..405
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 755..764
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 783..795
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 785..802
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 804..813
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 832..844
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 852..861
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1198..1207
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1350..1359
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1401..1410
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 2026 AA; 219699 MW; 8914366381305B00 CRC64;
MDFQRIAVYL TSVYCFLVVL PSINGDCADR ACFPPSPDLV SQESGRSVVA NSTCGDPPEV
TLEKLTNVQV TCNSSDPDLA RHVENLFDHN ILIAGSMYFR PVLRTWWQSQ TGAENVILSL
SLGDTFLFQA TQLVFQSLRP NSLVIEKSED HGQTWAPLRY YARSCAVSFP DVAFLAQDAF
EENHNVVSGC MQRYYYGDAA SFDSSNELQQ VLYNPVSELG ARFYQQDVLE FFRFTDIRIN
LVKPGSSDAG RDYFAVADWS VTGHCLCYGH AEKCIGQNEA SCVCEHNTMG QHCDQCKPLY
NNKPWEAAFM GHPNECEDCG CSGRSTSCTY NEVKGYGVCD NCTENSTGEK CDHCIEDFFI
NPGTGEADPF CIPCNCTAIG IVPGSVCNET QGQCVCKENV QGRQCHECKD SYYQLDRRND
QGCQNESKFH IFLCATVILE ALTEHPTSVI SSTVNVSVRP TWKELECDLC KPGFFNLSLA
DPDGCTPCDC NGGGALSNTC NNLTGLCDCK MNIGGRSCDV VDSGFYVPLL DGIKIEAELL
DTLQMASLLE RPETAMPKSS GRGLLLVPAA TSLTYPSMTV PRTQRYDIVV RYSTPSISSN
NRLSLSAPGN TISYSCAGSG SILEPPQLTF DLSETTNLSA VSIGQACLAA GIVYEPNFTA
GASLGSGLAI DTFVFLPVLA DLSVYTESGN ESLFIESCWE DAKVSDGVLR SEGNCSKVEF
VVMAELYNGA IGCTCNVSGS SNSASCDPLG GQCDCLPGVS GRECDYCSAY HYDFMPGVGC
QVCNCDPFGS QEQSCYLSGG VCDCKANVTG DRCDQCLPEH YGLNSGTGCA PCLCEPLYSL
HNQCNQTGQC DCKPGVSGLT CSTCLTGFFN LTSEGCQECL CNPLGSRDGI CRLDGQCDCL
EAAVGLKCDT CPDNTYSFGP YSERGCLDCI CSGHSVNCSM AANWYTHTLS SSWSLFAFDL
SPEWTGQTGS GDTVLINTRP ILDVLNPRFV LELEGRDAEE DLFFVSPDVY RGDLHTAYGQ
VLHFVLSQTT VENQSRFLDG DVFLYGLYSE EPLVTGLPSN PSLEETPYSF KLHERYWRIG
NMSGKQPDMV DMVRVLSALD QIKIRGKYTQ LVDNSVFLHE VRVTLASDDS ALSSNPPAEF
VEQCQCPDQY NGQFCESCML GYRWQDPSMG PFSDCVLCDC NSHSLLPCDI MSGRCSNCTH
NTAGDFCEIC ADGFYGNATI GSSDDCQPCM CPGPAGVNSF AGTCNDQGEC QGCSEGHGGL
QCEFCLSGFY GVPTDPQNNG GLCSQCFCNL SPHDCNSTTG YCGNCTGNTS GPTCGECQFG
YYGNIDNCME CNCNMTGSHG NCSDDGVCDC LPNVIGVKCT QCAPDSWGFE SGLGCTSCDC
HPAGTVIGQT QCDLVTGQCQ CKNSVSGLKC DMCQPGFWNV DAECIPCDCN KNGTDPATCV
DGLCSCDQVT GQCSCALPTI AGRTCDQCGR VNEASSEIAE VFVGTFPKCE PCPECFHRWR
AVLNEHITSL DGISALLKDI LLNYGNIPLQ EVDAQLQTIQ EELSSVQLAL QEGLVQAGNL
AALQNQYQEV FNEVISVNDS LAAVLASEAA LKESVQALGD FDGNVTIVDT ADTVTAKLIR
EGNLQQQATL DDIFLQANAS WVRIQQFYTT CVDASARTAS LLSEADGLMT EVDRSAQQRR
DTLDGLNDEQ QLQEREQNDQ RIDEIRGIHL SFDLETPVRD VSTAEGLAFT ARNISNGTVG
AALQEVDQTT ELSSEAGAAS TNTSRVQQLV AATQSKSQSY KMLALSVRSN ATMAYSDMLD
TLLALNGTAE SAAEASSLAA STLQYSVVLL ETWLPYHEAE AVQAHLRTIE YELGEGERIT
NKTQLDLESL IRDFSNTETI INEVQTKATE EVGRSSVLLD DISVLLQLSR TTEQCYRDNV
MMGQSATEKT QNSYTRLEES DIVITTASAR KDDFDSGLSS KSQEISQGAL DVEQLAASIN
TTEQELINIQ QQQNLDNLIS QYQAQRIEMQ RLLSNLNQME TSLDQI
//
