ID A0A2G8KMN9_STIJA Unreviewed; 2094 AA.
AC A0A2G8KMN9;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=U5 small nuclear ribonucleoprotein 200 kDa helicase {ECO:0000256|ARBA:ARBA00034541};
GN ORFNames=BSL78_13861 {ECO:0000313|EMBL:PIK49237.1};
OS Stichopus japonicus (Sea cucumber).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK49237.1, ECO:0000313|Proteomes:UP000230750};
RN [1] {ECO:0000313|EMBL:PIK49237.1, ECO:0000313|Proteomes:UP000230750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Shaxun {ECO:0000313|EMBL:PIK49237.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PIK49237.1};
RX PubMed=29023486;
RA Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT "The sea cucumber genome provides insights into morphological evolution and
RT visceral regeneration.";
RL PLoS Biol. 15:E2003790-E2003790(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIK49237.1}.
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DR EMBL; MRZV01000474; PIK49237.1; -; Genomic_DNA.
DR STRING; 307972.A0A2G8KMN9; -.
DR Proteomes; UP000230750; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProt.
DR CDD; cd18021; DEXHc_Brr2_2; 1.
DR CDD; cd18795; SF2_C_Ski2; 2.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 2.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041094; Brr2_helicase_PWI.
DR InterPro; IPR048863; BRR2_plug.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF6; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR Pfam; PF21188; BRR2_plug; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF18149; Helicase_PWI; 1.
DR Pfam; PF02889; Sec63; 2.
DR PIRSF; PIRSF039073; BRR2; 2.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00487; DEXDc; 2.
DR SMART; SM00490; HELICc; 2.
DR SMART; SM00973; Sec63; 2.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000230750}.
FT DOMAIN 485..664
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1284..1459
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT REGION 29..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..76
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..229
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2094 AA; 237977 MW; 929906817F1F5E83 CRC64;
MAGATARSLQ YEYKANSNLV LQADRSLIER RGRDEATGEV MSLSGRTTGS RMGDKAKRNK
PPMQEERKIK RQKRDDAKYD MNKFKGQTLL SEGIDDMVGI YYRPKTPETR TTYEALLSFI
QAALGDQPRD ILCGAADEVL ATLKNDNSRS KEKEKELELL LGKLAEERFA LLVNLGKKIT
DYGGDKDKNP IDETIGVNVQ FEESDAEDDP EDYGEVKDEE SESEEEGEEP ARDNALTTSL
AGGEALLGSQ KDLHPRDIDA YWLQRQLGTF YDDPNVSQAK AGEVLDILKD AADDGQVENQ
LVMLLGTNRF DFIKLLRKER QMILHCTLLA KAQNSAERAR LEEKMKAEPE LTAILEALTE
TEKEDLIQEE RARKAAARQT RVDADLEAME TDEADNNLAP QKLLDMDDLT FAQGSHLMAN
QKCQLPDGSF RKQRKGYEEV HVPALKPKPF DEDETLVYID KLPKYAQPAF EGFKSLNRIQ
SRLYKAALET DENLLLCAPT GAGKTNVALL TILREIGKNI NTDGTINTEA FKIIYIAPMK
SLVQEMVGNF RKRLSSYGIT VSELTGDTQL TKEQITATQI IVCTPEKWDI ITRKGGEKTY
TQLVRLIIID EIHLLHDDRG PVLECLIASF RPVPLEQQYI GITEKKAIKR FQLMNEIVYE
KVMDHAGKNQ VLVFVHSRKE TGKTARAIRD MCLEQDSLGQ FLKEGSASTE ILRTEADQAE
NLELKDLLSY GFAIHHAGMS KIDRTLVEDL FADRHIQVLV STATLAWGVN LPAHTVIIKG
TQPRKGTMGR AWPLDSFRCW GVLVDPVCTK GEGILITGHS ELQYYLSLQN QQLPVESQLV
SKMVDNLNAE VVLGNIQNMK DAINWLGYTY LYIRMMRNPT LYGIPVDAKD KDPYLEQFRI
DLIHTAAMVL DKNNLIKYDK KSGNFQMTEL GRIASHYYCT NDSMSTYNSL LKPTLSEIDL
FRVFSLSSEF RNMVVREEEK MELNMLLDRV PIPIKESIEE PSAKVNTLLQ AFISHLKLEG
FALVSDMVYI TQSAGRLIRA IFEIVLHRGW AQLTDKTLAL AKMIDKRMWQ SMSPLRQFKR
IPEEVTRKIE KKNFPWERFY DLGPNELGEL IRMPKMGKTI HKYIHFFPKL ELSAHIQPIT
RSTLRVELTI TPDFQWDEKV HGQSEAFWIL VEDVDSEIIL HHEYFLLKSK FAQDEHVVKF
FVPVFEPLPP QYFIRVVSDK WIGSETQLPV SFRHLLLPEK NAPPTELLDL QPLPVSALRN
PTFESLYSSK FSVFNPIQTQ VFYAVYNGDD NIFIIGAPTG SGKTVIGEMA ILRMLTQDSD
GRCVYVTPLD DVAEQIYNEW HAKFQMQLGK KVVLLTGETA TDLKLLAKGN IIVCTPDKWD
VLSRRWKQRK NVQSVNLFIV DELHLIGGDD GPILEVLCSR MRYISSQIER NIRIVSLSSS
LANAKDVAQW LGAAANNTFN FHPNVRPVSL ELHIQGFNIT HTASRLVAMV KPTYNAILKY
SPSKPVIVFV PSRKQTKLTA IDLLTYVSVE ESDESRFLHV DKKDLAAHLS KVTDETLREM
LENGIAYLHE GLSEIEQRVV EQLYSVGAIQ VVVASRNMCW GLTLSAHLAV IMDTQYYNGK
IHAYVDYPVT DVLQMVGRAN RPDIENEVSK CVILCQGSKK DFYKKFLYEP LPVESHLDHC
LHDHFNAEVV TKTIENKQDA VDYLTWTFLY RRMAQNPNYY GLQGITHRHL SDNLSELVES
TLQDLEHSKC VSIEDEMEIN PLNLGMIAAY YYINYTTIES FSMSLNNKTK IKGLIEIIAS
AAEYENIPIR HHEDSILKQL ASRVPNKLSQ ARYNDPHVKT NLLLQAHLGR MQLSAELQGD
TEEILSKALR LIQACVDVLS SNGWLSPALA AMELAQMVTQ AMWNKDSYLK QLPHFDSDLI
KRCMEKEVES IFDIMEMEDQ ERTDLLQLKD VQMADVARFC NRYPNIELTY EVQEKDSIES
GGPVVVMVTL EREDEITGPV IAPLFPQKRE EGWWVVIGDT KTNSLISIKR LTLQHKAKVK
LDFVAPSPGS HNYTIYYMSD AYMGCDQEYK FSIDVKEVAS DDESGDSQES SDED
//
