ID A0A2G8KN60_STIJA Unreviewed; 603 AA.
AC A0A2G8KN60;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Dishevelled {ECO:0000313|EMBL:PIK49454.1};
DE Flags: Fragment;
GN ORFNames=BSL78_13684 {ECO:0000313|EMBL:PIK49454.1};
OS Stichopus japonicus (Sea cucumber).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK49454.1, ECO:0000313|Proteomes:UP000230750};
RN [1] {ECO:0000313|EMBL:PIK49454.1, ECO:0000313|Proteomes:UP000230750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Shaxun {ECO:0000313|EMBL:PIK49454.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PIK49454.1};
RX PubMed=29023486;
RA Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT "The sea cucumber genome provides insights into morphological evolution and
RT visceral regeneration.";
RL PLoS Biol. 15:E2003790-E2003790(2017).
CC -!- SIMILARITY: Belongs to the DSH family. {ECO:0000256|ARBA:ARBA00008735}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIK49454.1}.
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DR EMBL; MRZV01000465; PIK49454.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G8KN60; -.
DR STRING; 307972.A0A2G8KN60; -.
DR Proteomes; UP000230750; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd04438; DEP_dishevelled; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.40.240.130; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR024580; Dishevelled_C-dom.
DR InterPro; IPR008339; Dishevelled_fam.
DR InterPro; IPR003351; Dishevelled_protein_dom.
DR InterPro; IPR001158; DIX.
DR InterPro; IPR038207; DIX_dom_sf.
DR InterPro; IPR015506; Dsh/Dvl-rel.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10878; SEGMENT POLARITY PROTEIN DISHEVELLED; 1.
DR PANTHER; PTHR10878:SF25; SEGMENT POLARITY PROTEIN DISHEVELLED; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF02377; Dishevelled; 1.
DR Pfam; PF12316; Dsh_C; 1.
DR Pfam; PF00595; PDZ; 1.
DR PRINTS; PR01760; DISHEVELLED.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50841; DIX; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000230750};
KW Wnt signaling pathway {ECO:0000256|PROSITE-ProRule:PRU00069}.
FT DOMAIN 1..28
FT /note="DIX"
FT /evidence="ECO:0000259|PROSITE:PS50841"
FT DOMAIN 192..265
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 365..439
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT REGION 25..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 501..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..85
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..116
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..171
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..517
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..554
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:PIK49454.1"
SQ SEQUENCE 603 AA; 65497 MW; 59BB9FC3E400C683 CRC64;
VVKEEIVDDE AKLPCFNGRV VSWLVPAEGS GGTPSELGSQ AGDSLPPERT GGIGDSRPPS
FHANAGSLSD KFEDTETESV ISSKRDRHRH AHIVRRDRYR DGFPRSKRDH HRTGHGYESS
STLMSSDIET TSFFDSTDDD SRFSSATERT GSSRQMRSKH RKRRKKPRMP RVQRASSFSS
ITDSTMSLNI ITVTLNLDKI NFLGISIVGQ SNKGGDGGIY VGSIMKGGAV AADGRIEPGD
MILQVNDVSF ENMSNDDAVR VLREAVHQPG PIKLVVAKCW DPTPKGYFTI PRSEPVRPID
PGAWVAHTNA MKVVDYQNRG GALSPSMTSM TSSSISSSLP ESEKEYTKLT INTDMATIAR
AMAVPDSGLD IRDRMWLKIT IPNAFLGSDV VEWLFQHVEG FQDRRDARKY ACNLLKANFI
RHTVNKITFS EQCYYVFGDL CGNMAALSLG DDAEADQDTL GPLPHQPPHW LPPGGTVPYQ
QAPVTTGYTS FDSQSYTSFG GTSIGSGSGG STGSTHSQER KEAAKARSKG SSGSGNDSDQ
ASIISGSRAP SQLGDGSTRG ELPPPHPPPH PRQLGLMTED LSASRQSFRM AMGNPSEFFV
DVM
//
