ID A0A2G8KNP5_STIJA Unreviewed; 547 AA.
AC A0A2G8KNP5;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE SubName: Full=Putative centromere protein T {ECO:0000313|EMBL:PIK49632.1};
GN ORFNames=BSL78_13491 {ECO:0000313|EMBL:PIK49632.1};
OS Stichopus japonicus (Sea cucumber).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK49632.1, ECO:0000313|Proteomes:UP000230750};
RN [1] {ECO:0000313|EMBL:PIK49632.1, ECO:0000313|Proteomes:UP000230750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Shaxun {ECO:0000313|EMBL:PIK49632.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PIK49632.1};
RX PubMed=29023486;
RA Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT "The sea cucumber genome provides insights into morphological evolution and
RT visceral regeneration.";
RL PLoS Biol. 15:E2003790-E2003790(2017).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CENP-T/CNN1 family.
CC {ECO:0000256|ARBA:ARBA00010137}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIK49632.1}.
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DR EMBL; MRZV01000455; PIK49632.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G8KNP5; -.
DR STRING; 307972.A0A2G8KNP5; -.
DR Proteomes; UP000230750; Unassembled WGS sequence.
DR GO; GO:0000776; C:kinetochore; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0051382; P:kinetochore assembly; IEA:InterPro.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR InterPro; IPR028255; CENP-T.
DR InterPro; IPR035425; CENP-T/H4_C.
DR InterPro; IPR009072; Histone-fold.
DR PANTHER; PTHR46904; CENTROMERE PROTEIN T; 1.
DR PANTHER; PTHR46904:SF1; CENTROMERE PROTEIN T; 1.
DR Pfam; PF15511; CENP-T_C; 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000230750}.
FT DOMAIN 444..537
FT /note="CENP-T/Histone H4 histone fold"
FT /evidence="ECO:0000259|Pfam:PF15511"
FT REGION 200..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 283..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..347
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 547 AA; 59591 MW; 6ECEFC9D7A98E89E CRC64;
MSSRKVTPRG IIQGVLEANS ITKSAVNTTR TRRRSLRRSL AEATPGTLIK GVLQTSSTAK
KSPARNTRVL PTPPLSAIRK SSRIARLQSS GSQDPTPRGL IRGLLASTAP ETPAAHVVVR
TSTDNESETD VQRNAYQGRI ADLISPDVDT PEVLSQERRT KGGIKRQRGV ANIPKDAFQS
GIHQRMQKDV ADVSSFSDST LHSIPEESEG RQTGRITTTN DEDVSSQEEM EVEIAALAQL
ATQPQTRTAG EDEELDILQD TSAVSLSNMS FGEVAAANTI QVHQVSDHQS MTQPASENSS
STEEDEPSSA KRQRTLIEKN SVTAKQRGTT QDVINRSGTS VVQDGEGTES PAESDEMLDI
SQPEAENLDG NTSDVSHTNE DEEQDISSIF SPMVTPSALL GGRRKTPAPK TPAAYKSQGR
RAQPPGTQRT LPRTRRSLRK PHALPLSLTK SIFTHFSNGS ISKGAWEAIE DCTDKFLEQV
TKDLAHYSSH AKRKTIHTED VILLMKRQGH VSDMQSFYAL VEKYLSMEQR RELIPCALAG
GGTKPDL
//
