ID   A0A2G8KQ13_STIJA        Unreviewed;       602 AA.
AC   A0A2G8KQ13;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=Heparan sulfate 6-O endosulfatase {ECO:0000313|EMBL:PIK50030.1};
GN   ORFNames=BSL78_13096 {ECO:0000313|EMBL:PIK50030.1};
OS   Stichopus japonicus (Sea cucumber).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC   Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX   NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK50030.1, ECO:0000313|Proteomes:UP000230750};
RN   [1] {ECO:0000313|EMBL:PIK50030.1, ECO:0000313|Proteomes:UP000230750}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Shaxun {ECO:0000313|EMBL:PIK50030.1};
RC   TISSUE=Muscle {ECO:0000313|EMBL:PIK50030.1};
RX   PubMed=29023486;
RA   Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA   Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA   Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA   Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT   "The sea cucumber genome provides insights into morphological evolution and
RT   visceral regeneration.";
RL   PLoS Biol. 15:E2003790-E2003790(2017).
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|ARBA:ARBA00001913};
CC   -!- SIMILARITY: Belongs to the sulfatase family.
CC       {ECO:0000256|ARBA:ARBA00008779}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PIK50030.1}.
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DR   EMBL; MRZV01000436; PIK50030.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2G8KQ13; -.
DR   STRING; 307972.A0A2G8KQ13; -.
DR   Proteomes; UP000230750; Unassembled WGS sequence.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR000917; Sulfatase_N.
DR   PANTHER; PTHR43108:SF16; EXTRACELLULAR SULFATASE SULF-1 HOMOLOG; 1.
DR   PANTHER; PTHR43108; N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER; 1.
DR   Pfam; PF00884; Sulfatase; 1.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000230750}.
FT   DOMAIN          13..175
FT                   /note="Sulfatase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00884"
FT   REGION          285..326
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          425..462
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   602 AA;  69751 MW;  6D1EA4ADF44FFECE CRC64;
     MSFFKVSKRA FPDGPVAMVL SFPSPHGPED CAPQYTEEFK NNQLHRTPSW NYGPNDDKHW
     LLQYTQQMTP LEQNFTDAMH RKRLLTLLSV DDAVDKVCRE LEAMGELDNT YIIYTSDHGY
     HLGQFGVLKG KSLPYDFDIR VPFYMRGPAI PHDIEVPNIV LNIDIATTLL DIAGAEIPSY
     MDGVSLLKLF LPRSNYRVHH KSKRWKYKGD EEWRDSFMVE RSRSPEDVER LIQRQLKAGA
     NSIAEMCKGE DYQYPCQEGQ GKYCEKDETG AWVVRKCVAY QCDCDDEDDE SSTERRRDDK
     RRRHTKRGSS RDKFGNLVRP RRSSARRNAV GGVPMCWVEK KVVKCSKEVL LEDSVIEAQE
     RLVKAHLRLY RRHITDLKHI HKYLKKAKGA NLIPFPESSR ANRNFSRSGK RKNCMCEELD
     PSEELPLGQS LQPYRRDRRN TGRRQSRKSG RKSKEKKELK EETGCKDAGM SCFYHDNTHW
     KTPPLWNDAP VCGCTNNQNN SYWCIRTINN THNFLYCEYV TGFLEYFDMR PSKDPYQLTN
     AIRELETNSK TVLSQEVRFL KVCYGFNQCT LNSTGKVAAQ SQPVIEPQRI EGLDGDENPS
     SR
//