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Database: UniProt
Entry: A0A2G8KS05_STIJA
LinkDB: A0A2G8KS05_STIJA
Original site: A0A2G8KS05_STIJA 
ID   A0A2G8KS05_STIJA        Unreviewed;       721 AA.
AC   A0A2G8KS05;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   05-DEC-2018, entry version 6.
DE   RecName: Full=Beta-galactosidase {ECO:0000256|RuleBase:RU000675};
DE            EC=3.2.1.23 {ECO:0000256|RuleBase:RU000675};
GN   ORFNames=BSL78_12353 {ECO:0000313|EMBL:PIK50767.1};
OS   Stichopus japonicus (Sea cucumber).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa;
OC   Holothuroidea; Aspidochirotacea; Aspidochirotida; Stichopodidae;
OC   Apostichopus.
OX   NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK50767.1, ECO:0000313|Proteomes:UP000230750};
RN   [1] {ECO:0000313|EMBL:PIK50767.1, ECO:0000313|Proteomes:UP000230750}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Shaxun {ECO:0000313|EMBL:PIK50767.1};
RC   TISSUE=Muscle {ECO:0000313|EMBL:PIK50767.1};
RX   PubMed=29023486;
RA   Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA   Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA   Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X.,
RA   Xing L., Huo D., Sun M., Wang L., Mercier A., Li F., Yang H.,
RA   Xiang J.;
RT   "The sea cucumber genome provides insights into morphological
RT   evolution and visceral regeneration.";
RL   PLoS Biol. 15:E2003790-E2003790(2017).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of terminal non-reducing beta-D-galactose
CC         residues in beta-D-galactosides.; EC=3.2.1.23;
CC         Evidence={ECO:0000256|RuleBase:RU000675};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC       {ECO:0000256|RuleBase:RU003679, ECO:0000256|SAAS:SAAS00534244}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:PIK50767.1}.
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DR   EMBL; MRZV01000405; PIK50767.1; -; Genomic_DNA.
DR   Proteomes; UP000230750; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 2.60.120.260; -; 3.
DR   InterPro; IPR026283; B-gal_1-like.
DR   InterPro; IPR025300; BetaGal_jelly_roll_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR   InterPro; IPR019801; Glyco_hydro_35_CS.
DR   InterPro; IPR001944; Glycoside_Hdrlase_35.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR23421; PTHR23421; 2.
DR   Pfam; PF13364; BetaGal_dom4_5; 1.
DR   Pfam; PF01301; Glyco_hydro_35; 1.
DR   PIRSF; PIRSF006336; B-gal; 2.
DR   PRINTS; PR00742; GLHYDRLASE35.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   PROSITE; PS01182; GLYCOSYL_HYDROL_F35; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000230750};
KW   Glycosidase {ECO:0000256|RuleBase:RU000675,
KW   ECO:0000256|SAAS:SAAS00108888};
KW   Hydrolase {ECO:0000256|RuleBase:RU000675,
KW   ECO:0000256|SAAS:SAAS00108869}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000230750};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     30     48       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       77    430       Glyco_hydro_35. {ECO:0000259|Pfam:
FT                                PF01301}.
FT   DOMAIN      488    563       BetaGal_dom4_5. {ECO:0000259|Pfam:
FT                                PF13364}.
FT   ACT_SITE    224    224       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR006336-1}.
FT   ACT_SITE    300    300       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR006336-1}.
SQ   SEQUENCE   721 AA;  82547 MW;  E1F3E927D3CB3949 CRC64;
     MQQQSRSTPS SVRTPAVFNM KAFSIRPVHL FRWCLIFFAF CAFIFWYVHR WNLAKQLSPL
     QTKLATKASM ETKGTDFYLD GKKLRILSGS MHYFRVVPEY WEDRLLKMKA GGLNTVTTYV
     PWNAHEPSRG TYHFKANLDI VEFLNVAKRV GLHVILRPGP YICAEWEFGG LPSWLLAEDE
     MEVRTMYPTF IDAMGKYFDE LIPKVVPLQY GNGGPIIAVQ VENEYGSFGK DKNYMKQVKE
     ALTSRGIVEM LVSSENGRIP MENAYLKDVL MTANFQENAD RHFDDLIRMQ GADKPVMVME
     FWTGWFDHWG EKHHIYSAED FSRLVEAVLK RQASINFYMF HGGTNFGFMN GGNFQNGPRK
     APVSANSNQL CFNSNRKPVW LISGTSLSRI PSQKCYAEQA NCWWTDYDAP IAEDGDITDK
     FLKIKELLKE YVPEETKNIP VLPADIPKRA YADVEITHYM PLDTLLEVNG KPIINDEILP
     MEKLPINGNS GQGYGYLLYR TYTQKKPTQL KFEHPPHDRA QIFLNGQPEG VVQRRHDTSE
     TVLELKGGKE GENSIEILVE NQGRVNYGHD IKIERKGIIG DVFVNGIMQE KWEMFPLEFK
     KSLLEAASNS IKWYETPAHE KRPALYKGHL EITDGTPADT FLDMSEWTKG VIFVNGFNLG
     RYWNVGPQWT YYLPGPLLHT GKNEIIIFEQ DQSAAALKFS DKPDLGTVVR VRNDEDIAPG
     L
//
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