ID   A0A2G8KSA3_STIJA        Unreviewed;       651 AA.
AC   A0A2G8KSA3;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   24-JAN-2024, entry version 12.
DE   RecName: Full=NACHT domain-containing protein {ECO:0000259|PROSITE:PS50837};
GN   ORFNames=BSL78_12230 {ECO:0000313|EMBL:PIK50886.1};
OS   Stichopus japonicus (Sea cucumber).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC   Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX   NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK50886.1, ECO:0000313|Proteomes:UP000230750};
RN   [1] {ECO:0000313|EMBL:PIK50886.1, ECO:0000313|Proteomes:UP000230750}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Shaxun {ECO:0000313|EMBL:PIK50886.1};
RC   TISSUE=Muscle {ECO:0000313|EMBL:PIK50886.1};
RX   PubMed=29023486;
RA   Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA   Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA   Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA   Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT   "The sea cucumber genome provides insights into morphological evolution and
RT   visceral regeneration.";
RL   PLoS Biol. 15:E2003790-E2003790(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PIK50886.1}.
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DR   EMBL; MRZV01000400; PIK50886.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2G8KSA3; -.
DR   STRING; 307972.A0A2G8KSA3; -.
DR   Proteomes; UP000230750; Unassembled WGS sequence.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR46312; NACHT DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR46312:SF1; NACHT DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF05729; NACHT; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS50837; NACHT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000230750}.
FT   DOMAIN          208..331
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
FT   REGION          171..191
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        172..191
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   651 AA;  73269 MW;  0B0F7873450D6F93 CRC64;
     MLRRLSTPKQ ASMDRKQASK NFGRFQVGLA NLLTIEIILK LSALFNLPPA KEDQIKNARS
     EQSTPSLLMV ATMKEMGIIN PLDISPLTKA LENLKLHGTL RDVQTLFQNY NENTEDSTDS
     KFHGKKDTFL SSLRKMYVSQ YDKIQPIPYI RDSVSVNDVF VEGGIEIQKN TQRLSRKAKT
     ESKDDDKPDV KPLKSHLDIF NEKEIDSKRI LVQGDPGFGK STFLMQTAYD WCFSDDSSPL
     RRIDAFVLLT LRLLGGKLSV YSAIQNLLIP GESMLTEEEI KEILVSLGSV VIAFDGYDEY
     PERDSELQTD IKDIIGGKMF SDFTVIICTR SACIPRNLDP NATRIRLTGF DNNAREEYIA
     KAVAGGDRKA VERIMQRLNG SPILSDICQV PMFCVMFAHI ADETEDLTVF STVTGFFHFM
     IHCFYGHMRG KSSESAEFDQ DIQSLPVFDK LNKLAFEGLT ASRQQLSWEQ NDFQKAVGLK
     CFSELTKIGI LVQEVAQEIN YSPGTSFTKQ VINTKSVRFF HKLFAEWYAA NYVAAHAGSV
     MTFRVDSLLK KISPVDLQFI FRFACGLNKK ASKRIIAYLN GIEDGKSFAS LCLFEQVKDI
     GDVTAVVEDL ISEGVTIRSS DTRLLQRSNK HLIDIASVNQ VRVSSKNIIL D
//