ID   A0A2G8KUK1_STIJA        Unreviewed;       881 AA.
AC   A0A2G8KUK1;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   22-FEB-2023, entry version 18.
DE   SubName: Full=Putative huntingtin-interacting protein 1 isoform X2 {ECO:0000313|EMBL:PIK51652.1};
DE   Flags: Fragment;
GN   ORFNames=BSL78_11462 {ECO:0000313|EMBL:PIK51652.1};
OS   Stichopus japonicus (Sea cucumber).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC   Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX   NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK51652.1, ECO:0000313|Proteomes:UP000230750};
RN   [1] {ECO:0000313|EMBL:PIK51652.1, ECO:0000313|Proteomes:UP000230750}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Shaxun {ECO:0000313|EMBL:PIK51652.1};
RC   TISSUE=Muscle {ECO:0000313|EMBL:PIK51652.1};
RX   PubMed=29023486;
RA   Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA   Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA   Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA   Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT   "The sea cucumber genome provides insights into morphological evolution and
RT   visceral regeneration.";
RL   PLoS Biol. 15:E2003790-E2003790(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PIK51652.1}.
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DR   EMBL; MRZV01000362; PIK51652.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2G8KUK1; -.
DR   STRING; 307972.A0A2G8KUK1; -.
DR   Proteomes; UP000230750; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0003779; F:actin binding; IEA:InterPro.
DR   GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR   GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR   GO; GO:0006897; P:endocytosis; IEA:InterPro.
DR   Gene3D; 1.20.5.1700; -; 1.
DR   Gene3D; 1.20.1410.10; I/LWEQ domain; 1.
DR   InterPro; IPR011417; ANTH_dom.
DR   InterPro; IPR035964; I/LWEQ_dom_sf.
DR   InterPro; IPR002558; ILWEQ_dom.
DR   InterPro; IPR030224; Sla2_fam.
DR   PANTHER; PTHR10407; HUNTINGTIN INTERACTING PROTEIN 1; 1.
DR   PANTHER; PTHR10407:SF15; HUNTINGTIN INTERACTING PROTEIN 1; 1.
DR   Pfam; PF07651; ANTH; 1.
DR   Pfam; PF01608; I_LWEQ; 1.
DR   SMART; SM00307; ILWEQ; 1.
DR   SUPFAM; SSF109885; I/LWEQ domain; 1.
DR   PROSITE; PS50945; I_LWEQ; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000230750}.
FT   DOMAIN          582..823
FT                   /note="I/LWEQ"
FT                   /evidence="ECO:0000259|PROSITE:PS50945"
FT   REGION          209..239
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          394..419
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          247..344
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          598..658
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          791..818
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        213..227
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        394..412
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:PIK51652.1"
SQ   SEQUENCE   881 AA;  99320 MW;  D38286C93F10DD7F CRC64;
     YPTIPGNLQL TDPETALEKI AENDINNLFQ MSVEIFDYLD ALINLEEAIF GSFDLSKNIS
     TTASGQCRLA PLIPVVVDSG QLYDFSVRLL YKLHACLPQD TLSGHRQRFL KQFEALKAFY
     TKTSTLIYFK HYIQVPSLPK SPPNFFVKAN SEATYITQAV MLDLLEGDSG RDSPQASREP
     SLFEEPIIYP PAAPQPVQAQ RENDIFGSPN LLVDLTSPKS NGQVQRSPAT PPPLPVRHVP
     DERDRLIEQL RLEIENLKFE LERTKMEDQR IIEMLKRRLM EMEMEMNEHQ TVIETQCQEN
     EDLRAEVTQL AMAGSAIASS QERVQELEAK ARSNEDKFQK MKEVYQSIRD EHVNLLRKHA
     DVTKQLGKVQ KTTEEQEMAR LNAERFVERL QQSVEEKNAK GDDQERGRLS EESPSLDAIN
     SAQSSLRRTM EDMDDPSYAT ATCTAEYLLS RSAGVDDALR HLEESIRRYE QNDMEVGNFC
     KHRDLLQHPR IVSYEGEGHF KHGACRQRRE KVSVEIYSYL IIFFHLNNVG LSNACHDACH
     RAIDLVITLQ ESTGTGRFVN QRNQVDQHLK EISRVAELLH SGEGDISEEL GDLVDKEMQS
     TTDAILQAEK RIEDMLRKSQ EADSGVKLEV NGRILDSCTE LMKYIKALIE NSKNLQREIV
     STGKGSATSK DFYKRHHRWT EGLISAAKLV GVGATHLVDA SDKVVQGKEK FEALIVCSSE
     IAACTAQLVA ASRVKSDKGS ANLKELQVAS KGVASATAKV VASAKTGAEM IDEKESMDFT
     NLSLTQTKRL EMESKIRVLE LENNLEKERK KLDELRKVHY QLAGSSEGWD EGNTLACGIA
     ANCSYPFLHK FVSGRGGGRR EVLGRGRYIK CEEFHPMKCL C
//