ID A0A2G8KUV6_STIJA Unreviewed; 1314 AA.
AC A0A2G8KUV6;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE SubName: Full=Putative two pore calcium channel protein 1 isoform X3 {ECO:0000313|EMBL:PIK51700.1};
GN ORFNames=BSL78_11420 {ECO:0000313|EMBL:PIK51700.1};
OS Stichopus japonicus (Sea cucumber).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK51700.1, ECO:0000313|Proteomes:UP000230750};
RN [1] {ECO:0000313|EMBL:PIK51700.1, ECO:0000313|Proteomes:UP000230750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Shaxun {ECO:0000313|EMBL:PIK51700.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PIK51700.1};
RX PubMed=29023486;
RA Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT "The sea cucumber genome provides insights into morphological evolution and
RT visceral regeneration.";
RL PLoS Biol. 15:E2003790-E2003790(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIK51700.1}.
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DR EMBL; MRZV01000360; PIK51700.1; -; Genomic_DNA.
DR STRING; 307972.A0A2G8KUV6; -.
DR Proteomes; UP000230750; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR46726:SF2; SH3 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46726; TWO PORE CHANNEL 3; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000230750};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 300..318
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 330..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 371..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 431..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 472..491
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 511..534
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 721..738
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 774..797
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 845..865
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 890..909
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 982..1040
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 931..981
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1035..1108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1139..1258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1273..1314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..33
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..132
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 965..981
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1039..1056
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1063..1106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1139..1158
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1170..1184
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1214..1230
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1274..1295
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1314 AA; 148855 MW; 79E5503057DDC778 CRC64;
MDKEEEEETP KDGDEAKDRE DESMEETGKD SHVAAYRDFI IQMEREIATS PEEQSPNRPL
VQVTEEGVSI RDGPSVPSFN FQDGPSEKDP TPPGRDDSPE TKSNNSSGRN SPFKNRVEPL
VEDVEKNTNS DRAEELSSTN LSEMFVSSRR PLITSEFVPE YERNGLKTNS PDSGVEHDLD
CNGIDRPISK PSLGVGSKRK ISDKNYTRRI FVRTFKERAS QENFALYGLL TPALCLVPSI
DGNDSLTESF TELKGEDREL KLAAAHVDDA ITGRGKYGRA RAFFKPSYGR WSFNILVSQW
FHYLVLTVAT VHIALTFVEP PPNPESTSLV PIIVTPLCLL VYIADIAVHV GFLSWKVFWQ
WNENKWQRVE FVFVIVFTLD YIMLVIQWIL GMRLLQPFRC LRAAIILVKL KNVQHVYGVV
MSIVIKLGKV FLIIIIFILM FSAVGVNIFM SFYHCIGQNT TQTNCTESPN EIYTGSFDNV
AITFLRLFVL LSTENYPEVM IPAYSQSKVT FIYFGIFFFV GVFFLTAILL AIVVDSYWEF
AKKHVKEERS RERAELAKAW NLLDPLGKGS LPITDERFLK LFKILKPSNT EEMNMQLINY
LDSNNDGQID SAWNGPSGST RLSALISRWK TQEPIFNPHV LISLPQQCGP KWMKAVGSFA
QKIVRSDVFS KCSFLFAVAW ILMLVSLGIQ IAKTVILVVF MVEIVLSVFG ECLNLLHIIE
VLDIVLILVA MAANIAWYLC PDEFRGVCNV ISGLAVAFRV GFNSLQTKKT VIMFFTKIFP
VMSDLIILIL IIGYFYAVLG WESFSHIKPN LSYEADHYNY ECGLGFDTFA LCYQPVLGHV
STFDLFSVIN MVVMNLFVAI AIEAFNKLGK EKELETGIQK QKTKNNQKSL LFFFHCCTLG
NNLFTLQSMT MQHVPLPGLV FDDLPPHRLA PISAHPHSLQ KQEKVEEEDE PEEDEDLSHL
TPQERKKKMM KKKLERKRRK KKALQTIVVT TAFRASKDQE ISLNVGEQVE ILQKQEEWWE
GQIAGRRGWF PSSHVKEVKK STQPVKTRHM SLDREGRPAW ENSQTGLDRS QSVVQKPTYD
KTPSTDTLNT SLGSTGGRSS KPKLKLRSSG NWRKEILGDI TVINPQELKE LNKILKAQHS
ISSTSKLKSS GSLRKSPSIS ESIEEEPEPE VSLPVPPKTQ SSPRPKMLPP KISFDRAPTL
PLLEEEEEEE EDAKQPPPDK HYDADREDTL TVEQPSLPPE LKKKRNKEQN KSGEMPSWMA
KFVETNNLSI TTDVKFDDDG KQTQDEQKQD EDGTIESIKS QSIPGIVIEE DTPV
//
