ID A0A2G8KX74_STIJA Unreviewed; 733 AA.
AC A0A2G8KX74;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Putative set1/Ash2 histone methyltransferase complex subunit ASH2-like {ECO:0000313|EMBL:PIK52591.1};
GN ORFNames=BSL78_10533 {ECO:0000313|EMBL:PIK52591.1};
OS Stichopus japonicus (Sea cucumber).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK52591.1, ECO:0000313|Proteomes:UP000230750};
RN [1] {ECO:0000313|EMBL:PIK52591.1, ECO:0000313|Proteomes:UP000230750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Shaxun {ECO:0000313|EMBL:PIK52591.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PIK52591.1};
RX PubMed=29023486;
RA Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT "The sea cucumber genome provides insights into morphological evolution and
RT visceral regeneration.";
RL PLoS Biol. 15:E2003790-E2003790(2017).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIK52591.1}.
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DR EMBL; MRZV01000323; PIK52591.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G8KX74; -.
DR STRING; 307972.A0A2G8KX74; -.
DR Proteomes; UP000230750; Unassembled WGS sequence.
DR GO; GO:0048188; C:Set1C/COMPASS complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd15583; PHD_ash2p_like; 1.
DR CDD; cd12872; SPRY_Ash2; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.90.980.20; -; 1.
DR InterPro; IPR037353; ASH2.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR PANTHER; PTHR10598; SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2; 1.
DR PANTHER; PTHR10598:SF0; SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2; 1.
DR Pfam; PF21198; ASH2L-like_WH; 1.
DR Pfam; PF00622; SPRY; 2.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000313|EMBL:PIK52591.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000230750};
KW Transferase {ECO:0000313|EMBL:PIK52591.1};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00146}.
FT DOMAIN 198..253
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 461..649
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 1..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..42
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..75
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..391
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..421
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 733 AA; 81432 MW; C60F93E9A4F2263B CRC64;
MDEPTEKADS ELTSSLASDK KQEGTTTSTV HQQDQTLDTA GSETLIEKKP DSGKESPKEK
VDQSNTEKPA SEMEIDEPSD SQDNAAEQAD TQVTFDPPGI AQTDLNQEES GGESLDSKET
ETVEIGPTGE TASIEEDISM EITDGQEVEL MDTSGIETAS EETTTVTTET AVTEQRLGRE
EAVTEQSSTV EASEKGGKPT CCYCGRGRNL DVVELQCSIC MKWFHKDCLS INLGNCIPFM
MSYTFCCKRC NPNNVEMYSR KVPNFSVLCY VVLANLTAQS RKADPPKTMF SKDGDIIPFI
DANWELLTPA QRRTTVTWHS TIVKAMMKDA EMFVFKEKPD NPDENDEEYP LFGLLDQDLS
KIGPNYDPRG DATQKSGSLS SSLNGNSGLL MTNVGRGRGA RKRGLDSSQN LGANKKTKGE
LSASLRVSQH GYPLEHPFNK DGYRYTLTEN DPHAPAALFD EDIWIGKPIP AHLYRKALST
QVLLALHDRA PQLKISSDRL TVSGEKGYSM VRSTHGVRYG TWYFEVTINE MPENTATRIG
WSQPLGNLQA PLGYDKFGYS WRSRKGTKFH QSRGTRYTDG YGEGDVLGCL ILLPENIDKS
RILPDTYKNR TLIKFKSHLY FEEKDEPTET EKSLKVTPGS KISFYKNGKN QGTAFSDIHD
GLYYPCVSLY KSCSATVNFG PKFKHPPTDV GDYKPISDLA EISQVEQTLS DAIFHVEHEK
MYEDAARGIL VVF
//
