ID A0A2G8KZG0_STIJA Unreviewed; 786 AA.
AC A0A2G8KZG0;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN ORFNames=BSL78_09772 {ECO:0000313|EMBL:PIK53355.1};
OS Stichopus japonicus (Sea cucumber).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK53355.1, ECO:0000313|Proteomes:UP000230750};
RN [1] {ECO:0000313|EMBL:PIK53355.1, ECO:0000313|Proteomes:UP000230750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Shaxun {ECO:0000313|EMBL:PIK53355.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PIK53355.1};
RX PubMed=29023486;
RA Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT "The sea cucumber genome provides insights into morphological evolution and
RT visceral regeneration.";
RL PLoS Biol. 15:E2003790-E2003790(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIK53355.1}.
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DR EMBL; MRZV01000291; PIK53355.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G8KZG0; -.
DR STRING; 307972.A0A2G8KZG0; -.
DR Proteomes; UP000230750; Unassembled WGS sequence.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 1.
DR CDD; cd00047; PTPc; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR19134:SF461; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE ZETA; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000313|EMBL:PIK53355.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000230750};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}.
FT DOMAIN 14..114
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 235..490
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 407..481
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 512..768
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 686..759
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 173..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 786 AA; 90245 MW; 599DBC3C972537CB CRC64;
MRIYFPGLLE LPLLISTPEV VSIFDGSVTI SWSPWEEGIN NGDGPVVGYT LYFREDKVTR
WSKSGYVSAS EPREYMYTNL EPETSYMFSV AAVRVGDGGE GPRGPSLNVT TNCKVPLSPF
NVSAETKEGN YYVVIISWQG HFGRCSPSPL PPPMRRDRGL ELAHERTKRC IQKEESSFEN
SLREEGVDRN VPDTDHDITD QAIPVYDNVQ QPAPIPLTEL ASYITKCQSG TVDNFNHQFM
LLKEGKQYQS TIGEKEENKE KNRFKNMLPY DHSRVVLESH GGDPHSDYYN ANYIKGLNGD
KTFIACQGPN KASINDFWRM IWQENVHNIV MLTNLVERGR DRCLQYWPKA EKESRFFGEI
NVTWLCSETV ADFATRTMTV TWGEETRAVR IFHFLTWPDM DIPDQPTPLI TLTKKVKSVQ
ENVSSPLVVH CSAGIGRTGT FIGLYTLIDF LNGSEKIDVF GYVQEMRENR IDMIQRPTQY
VFLHECLLEE YLTGKTWIPT ESIIALSLDQ NKKKIFKQLK VHSELDSRDT NHTSCPPTEP
ERVRFPDVTP VSNKLLFTRS IGKMHADGYI NAFEVDSYSR RQAFIVTQSP LPNTVEDFWR
LVFDWKCSLI VMLNGLDPND ETCVQYWPDR NTVEYGFMTV ELSDSNEQAG YYYKHFNVSH
IDSQRKAKVH QLQIKSWDEN DMPGILQFIH VVQTMQDEYS SDSPVLVHCI NTVGRSGVFL
CVKSEIERMQ AEQRVDIFNT VRQLRASNRH FMQSEEDYIL CHQLLNLHVS SAELTEPPIY
ANLTEL
//
