ID   A0A2G8L018_STIJA        Unreviewed;       432 AA.
AC   A0A2G8L018;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   24-JAN-2024, entry version 11.
DE   SubName: Full=Endonuclease-reverse transcriptase {ECO:0000313|EMBL:PIK53623.1};
GN   ORFNames=BSL78_09476 {ECO:0000313|EMBL:PIK53623.1};
OS   Stichopus japonicus (Sea cucumber).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC   Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX   NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK53623.1, ECO:0000313|Proteomes:UP000230750};
RN   [1] {ECO:0000313|EMBL:PIK53623.1, ECO:0000313|Proteomes:UP000230750}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Shaxun {ECO:0000313|EMBL:PIK53623.1};
RC   TISSUE=Muscle {ECO:0000313|EMBL:PIK53623.1};
RX   PubMed=29023486;
RA   Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA   Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA   Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA   Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT   "The sea cucumber genome provides insights into morphological evolution and
RT   visceral regeneration.";
RL   PLoS Biol. 15:E2003790-E2003790(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PIK53623.1}.
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DR   EMBL; MRZV01000279; PIK53623.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2G8L018; -.
DR   STRING; 307972.A0A2G8L018; -.
DR   Proteomes; UP000230750; Unassembled WGS sequence.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR027124; Swc5/CFDP1/2.
DR   PANTHER; PTHR23227; BUCENTAUR RELATED; 1.
DR   PANTHER; PTHR23227:SF67; CRANIOFACIAL DEVELOPMENT PROTEIN 1; 1.
DR   Pfam; PF03372; Exo_endo_phos; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
PE   4: Predicted;
KW   Endonuclease {ECO:0000313|EMBL:PIK53623.1};
KW   Hydrolase {ECO:0000313|EMBL:PIK53623.1};
KW   Nuclease {ECO:0000313|EMBL:PIK53623.1};
KW   Nucleotidyltransferase {ECO:0000313|EMBL:PIK53623.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000230750};
KW   RNA-directed DNA polymerase {ECO:0000313|EMBL:PIK53623.1};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000313|EMBL:PIK53623.1}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           26..432
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5013890012"
FT   DOMAIN          19..127
FT                   /note="Endonuclease/exonuclease/phosphatase"
FT                   /evidence="ECO:0000259|Pfam:PF03372"
SQ   SEQUENCE   432 AA;  49108 MW;  94CAC9BCF50441A9 CRC64;
     MAVRLKLKIG TLLVIAVYAP TSVAADDVIS AFYHQLDRWI HDNLKTNEKL IVAGDFNAKL
     GTERINVSVL GPYGYGERNE RGDRLIDFCT SNNLTAAHTW FRKRPSRKVT WTSRANNARN
     AIDHILIDCA TKPTKQQPKP DLNSLRDPTT TQTLCDAVRD KLHEFNKLDE ISTLIHTNAV
     EACNVAPFRI NQPYLTPTTI QLIQDKREAR NTADFPRLRN AVKRACKGDM EKWLLQQVET
     INHAFSTNDT RTLFKTTNLL TVKPIAPLAN IKDKNGCVLL TVDDEVQRWE EYARELFHSD
     NQRPAVIRYP CTPHPPTSEE INTAIKSLKN NKAPGSDLVL SEFIKSVAED AHIRLALDKA
     VQDMWLTGTW PYSLTNSSYI VLHKKNDRGN CSNYRTLALI SHMSKMILNI IQQRLIPFVA
     IEFQMHSVDL SR
//