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Database: UniProt
Entry: A0A2G8L4C2_STIJA
LinkDB: A0A2G8L4C2_STIJA
Original site: A0A2G8L4C2_STIJA 
ID   A0A2G8L4C2_STIJA        Unreviewed;       925 AA.
AC   A0A2G8L4C2;
DT   31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT   31-JAN-2018, sequence version 1.
DT   05-JUN-2019, entry version 7.
DE   SubName: Full=Putative tolloid-like protein 1 {ECO:0000313|EMBL:PIK55113.1};
GN   ORFNames=BSL78_08008 {ECO:0000313|EMBL:PIK55113.1};
OS   Stichopus japonicus (Sea cucumber).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa;
OC   Holothuroidea; Aspidochirotacea; Aspidochirotida; Stichopodidae;
OC   Apostichopus.
OX   NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK55113.1, ECO:0000313|Proteomes:UP000230750};
RN   [1] {ECO:0000313|EMBL:PIK55113.1, ECO:0000313|Proteomes:UP000230750}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Shaxun {ECO:0000313|EMBL:PIK55113.1};
RC   TISSUE=Muscle {ECO:0000313|EMBL:PIK55113.1};
RX   PubMed=29023486;
RA   Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA   Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA   Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X.,
RA   Xing L., Huo D., Sun M., Wang L., Mercier A., Li F., Yang H.,
RA   Xiang J.;
RT   "The sea cucumber genome provides insights into morphological
RT   evolution and visceral regeneration.";
RL   PLoS Biol. 15:E2003790-E2003790(2017).
CC   -!- SIMILARITY: Belongs to the peptidase S8 family.
CC       {ECO:0000256|RuleBase:RU003355, ECO:0000256|SAAS:SAAS01077246}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:PIK55113.1}.
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DR   EMBL; MRZV01000225; PIK55113.1; -; Genomic_DNA.
DR   Proteomes; UP000230750; Unassembled WGS sequence.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   CDD; cd00041; CUB; 4.
DR   CDD; cd04077; Peptidases_S8_PCSK9_Proteinase; 1.
DR   Gene3D; 2.60.120.290; -; 4.
DR   Gene3D; 3.30.70.80; -; 1.
DR   Gene3D; 3.40.50.200; -; 1.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR034193; PCSK9_ProteinaseK-like.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR   InterPro; IPR022398; Peptidase_S8_His-AS.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   InterPro; IPR010259; S8pro/Inhibitor_I9.
DR   InterPro; IPR037045; S8pro/Inhibitor_I9_sf.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   Pfam; PF00431; CUB; 4.
DR   Pfam; PF05922; Inhibitor_I9; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SMART; SM00042; CUB; 4.
DR   SUPFAM; SSF49854; SSF49854; 4.
DR   SUPFAM; SSF52743; SSF52743; 1.
DR   PROSITE; PS01180; CUB; 4.
DR   PROSITE; PS00136; SUBTILASE_ASP; 1.
DR   PROSITE; PS00137; SUBTILASE_HIS; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000230750};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS01008102};
KW   Hydrolase {ECO:0000256|RuleBase:RU003355,
KW   ECO:0000256|SAAS:SAAS01077244};
KW   Protease {ECO:0000256|RuleBase:RU003355,
KW   ECO:0000256|SAAS:SAAS01099369};
KW   Reference proteome {ECO:0000313|Proteomes:UP000230750};
KW   Serine protease {ECO:0000256|RuleBase:RU003355,
KW   ECO:0000256|SAAS:SAAS01099373}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    925       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5013856328.
FT   DOMAIN      409    522       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      530    643       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      681    794       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      810    925       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   REGION      643    676       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2G8L4C2}.
SQ   SEQUENCE   925 AA;  99340 MW;  586805070857603E CRC64;
     MTMASHAVLI ICMLLSTVYG SDTDHNLAKE GNSRFIVSLK SQASTDLILD KLMNNLDMSS
     LRILHRYERA LNGFAAELSD TAVELLKQFK EVEYIEAEAV FSANQNLPWN IDRIDQLALP
     LDGFYGPIGS GSDVDVYVVD SGIYPSHNDF QGRASVAYDA LSGNGVDCNG HGTHCAGLVG
     GTTYGVAKTT NLLGVRVLDC NGDGNSMEII SGIDWIIANA ELPAVVSISF SGAGSTALDE
     AVSNMITAGL VVVASSGNNQ EDACSFSPGR IQEVITVAAT DESDTRAYFS NYGACVDLFA
     PGVDIESAWI GGADATNVLS GTSLASPHVA GAAAIILAND DQLTPAEVKD ALLSRAVTGV
     VQLAGTNSPN SFLYVGFGDG PNTPPPTLAI YKVIKCIYQK KNKYPIFDCS DTITEDGGEV
     KSPNYPGNYG NGEDCGWSIT APVGYVITLT FDMFDVEEGD TCQYDVLEVY DNASPITQYK
     IGSYCGNSIP GPFISTGNHM YLEFTSDQDL TAPGFHATVV FEEMSGECSC PGTCNFAARQ
     FTSPNYPNNY DNSALCNYQF TVPAGNLIRI DWLDFNVEQS VLGGCFDSVT VYDGVDDTYP
     EIDEFCGTST PDPVFSSGNE IFLVFTTDSS VVRSGFNAVY SPVSTTPTTR SPTTAAPPAT
     TVATSPPGNT TSTPQPEECS CPDTCHLSIG QFNSPNYPDQ YEIDSYCEYT FTVTPGKAVI
     VTWIEFDVEQ GILGPCFDSV TVYDGVNSSY PQIGLYCGDT IPDPVVSSQN NIFIVFQSDS
     VIVRDGFLAT FNETDVPTMP PTPTPPDSFC GNNYMDENTI VTSPDYPANY PRSSNCGNTI
     TAPIGQRIEF TFLTMDIEEE ENCQFDSVQL FDGDEANEEM SLSPPLCGTT LPPNPFNSTS
     NTMYVLFQSD LTQQQQGFSA SLRFF
//
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