ID A0A2G8L6P0_STIJA Unreviewed; 686 AA.
AC A0A2G8L6P0;
DT 31-JAN-2018, integrated into UniProtKB/TrEMBL.
DT 31-JAN-2018, sequence version 1.
DT 24-JAN-2024, entry version 11.
DE RecName: Full=NLR family CARD domain-containing protein 4 {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=BSL78_07167 {ECO:0000313|EMBL:PIK55939.1};
OS Stichopus japonicus (Sea cucumber).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Holothuroidea;
OC Aspidochirotacea; Aspidochirotida; Stichopodidae; Apostichopus.
OX NCBI_TaxID=307972 {ECO:0000313|EMBL:PIK55939.1, ECO:0000313|Proteomes:UP000230750};
RN [1] {ECO:0000313|EMBL:PIK55939.1, ECO:0000313|Proteomes:UP000230750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Shaxun {ECO:0000313|EMBL:PIK55939.1};
RC TISSUE=Muscle {ECO:0000313|EMBL:PIK55939.1};
RX PubMed=29023486;
RA Zhang X., Sun L., Yuan J., Sun Y., Gao Y., Zhang L., Li S., Dai H.,
RA Hamel J.F., Liu C., Yu Y., Liu S., Lin W., Guo K., Jin S., Xu P.,
RA Storey K.B., Huan P., Zhang T., Zhou Y., Zhang J., Lin C., Li X., Xing L.,
RA Huo D., Sun M., Wang L., Mercier A., Li F., Yang H., Xiang J.;
RT "The sea cucumber genome provides insights into morphological evolution and
RT visceral regeneration.";
RL PLoS Biol. 15:E2003790-E2003790(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PIK55939.1}.
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DR EMBL; MRZV01000195; PIK55939.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2G8L6P0; -.
DR STRING; 307972.A0A2G8L6P0; -.
DR Proteomes; UP000230750; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46312; NACHT DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46312:SF1; NACHT DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF05729; NACHT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000230750};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 408..431
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 290..393
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 539..662
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT NON_TER 686
FT /evidence="ECO:0000313|EMBL:PIK55939.1"
SQ SEQUENCE 686 AA; 78518 MW; D46B4677ADC2D787 CRC64;
MKPILLYKDG VKTGDGFDSG EFDIYPNGSL VIRYVTTNYE SVYTVSKVIS RLDLPVSYDK
HVQTTVTPAT TIPAVDQCSY VFDDICVKRT VRHIEVTCSI KESRPAVYLS WAKRTHERDY
ILPSNYMNFT KSNVPYTSRT TTKFLFEDSI FLTLLVCHAS SVPLNLMKQE NIILIERQTD
YTSIFTPDKS YVKIQSRMNL SCYDRTLNLL MWKRSRGREA DVETMFVSIF FQQSYLTQLT
YKECQLEVDG SISLQNTLLE HERLYACLHD NGVSGGIKLH NVSVIVDPIP AFPVVDGCNH
QQYCVLEKEP RDQLTCSVLG IRPEVSLEWR AFRQETPIVF TQHVLKVTKE GDGYDVSLTV
NFDITLTAQD KITVECHVVG DNSELFGLST KVDLLFNNVL LRDRDSNILA IAIIVGALIT
LIVIISVVLV SRCRKRRASR RKPVGIVINE VEETIPMMKS DTCYSEKAER FIKQLKAKYE
IFYDSVQPIP YIKDRMYCVD KEFVEGGIEI MTGISDGEAQ WDKLSSYQEL VTEYCLKTKR
HILEGEPGYG KSTLTLQLLY DWCKSLFKYP FRGVDVIIYL RLRQLSGVKS ILSAIKRFIL
PMDSDISERD TKEILNQMKS VLALLDGFDE YPDQESTETD IYHIMKKNLF QEFNVILTTR
PSCVPQGIAP QSDRGRLTGF AEEARK
//
